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“数字地球”作为新世纪信息时代的新目标和制高点,必将在西部大开发战略的实施过程中起到至关重要的作用。从“数字地球”的基本概念出发,应用“数字地球”的理论和技术,阐述了“数字地球”技术对西部大开发的战略意义和应用方向,为我国西部地区的可持续发展提供了新的思路和技术方法。 相似文献
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LJ. Kržalić V. Mandić LJ. Mihailović 《Cellular and molecular life sciences : CMLS》1962,18(8):368-369
Résumé Les auteurs ont déterminé par la méthode de la chromatographie à deux dimensions, la teneur en glutamine et en acide -aminobutyrique des différentes parties du cerveau du chat. La concentration la plus élevée de l'acide -aminobutyrique a été trouvé dans l'hypothalamus, tandis que celle de la glutamine a été constatée dans le noyau caudé. Les concentrations les plus basses de ces deux protéines apparaissent dans la substance blanche du cerveau. 相似文献
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Laurie CC Laurie CA Rice K Doheny KF Zelnick LR McHugh CP Ling H Hetrick KN Pugh EW Amos C Wei Q Wang LE Lee JE Barnes KC Hansel NN Mathias R Daley D Beaty TH Scott AF Ruczinski I Scharpf RB Bierut LJ Hartz SM Landi MT Freedman ND Goldin LR Ginsburg D Li J Desch KC Strom SS Blot WJ Signorello LB Ingles SA Chanock SJ Berndt SI Le Marchand L Henderson BE Monroe KR Heit JA de Andrade M Armasu SM Regnier C Lowe WL Hayes MG Marazita ML Feingold E Murray JC Melbye M Feenstra B Kang JH Wiggs JL 《Nature genetics》2012,44(6):642-650
We detected clonal mosaicism for large chromosomal anomalies (duplications, deletions and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for genome-wide association studies. This detection method requires a relatively high frequency of cells with the same abnormal karyotype (>5-10%; presumably of clonal origin) in the presence of normal cells. The frequency of detectable clonal mosaicism in peripheral blood is low (<0.5%) from birth until 50 years of age, after which it rapidly rises to 2-3% in the elderly. Many of the mosaic anomalies are characteristic of those found in hematological cancers and identify common deleted regions with genes previously associated with these cancers. Although only 3% of subjects with detectable clonal mosaicism had any record of hematological cancer before DNA sampling, those without a previous diagnosis have an estimated tenfold higher risk of a subsequent hematological cancer (95% confidence interval = 6-18). 相似文献
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