排序方式: 共有4条查询结果,搜索用时 0 毫秒
1
1.
2.
Claire Bardet Sidney Delgado Jean-Yves Sire 《Cellular and molecular life sciences : CMLS》2010,67(2):305-320
In mammals, the matrix extracellular phosphoglycoprotein (MEPE) is known to activate osteogenesis and mineralization via a
particular region called dentonin, and to inhibit mineralization via its ASARM (acidic serine-aspartate rich MEPE-associated
motif) peptide that also plays a role in phosphatemia regulation. In order to understand MEPE evolution in mammals, and particularly
that of its functional regions, we conducted an evolutionary analysis based on the study of selective pressures. Using 37
mammalian sequences we: (1) confirmed the presence of an additional coding exon in most placentals; (2) highlighted several
conserved residues and regions that could have important functions; (3) found that dentonin function was recruited in a placental
ancestor; and (4) revealed that ASARM function was present earlier, pushing the recruitment of MEPE deep into amniote origins.
Our data indicate that MEPE was involved in various functions (bone and eggshell mineralization) prior to acquiring those
currently known in placental mammals. 相似文献
3.
4.
E Bourret M Bastide J M Bastide L Bardet 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1977,284(12):1123-1126
The hemolytic activity of human complement is evaluated after diffusion in agarose containing sensitized erythrocytes. The results show a linear relation between hemolysis area and logarithm of concentration. 相似文献
1