The rule of law: Natural,human, and divine

In this paper we compare two different contexts—the legal and the scientific—in which the concept of law is prominent. We argue that the acute philosophical awareness, in the early modern period, of the difficulties surrounding the law concept in the scientific context, and the various responses to these difficulties, are rooted in an earlier tradition of jurisprudential concerns over the concept of natural law in its legal sense. We seek to show, further, that each one of the various philosophical accounts of the concept of natural law (in both of its senses) is embedded in a metaphysical and theological context, so that different visions of God yield different accounts of the meaning of the natural law idiom in science as well as legal theory.     

Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans

More than a billion humans worldwide are predicted to be completely deficient in the fast skeletal muscle fiber protein alpha-actinin-3 owing to homozygosity for a premature stop codon polymorphism, R577X, in the ACTN3 gene. The R577X polymorphism is associated with elite athlete status and human muscle performance, suggesting that alpha-actinin-3 deficiency influences the function of fast muscle fibers. Here we show that loss of alpha-actinin-3 expression in a knockout mouse model results in a shift in muscle metabolism toward the more efficient aerobic pathway and an increase in intrinsic endurance performance. In addition, we demonstrate that the genomic region surrounding the 577X null allele shows low levels of genetic variation and recombination in individuals of European and East Asian descent, consistent with strong, recent positive selection. We propose that the 577X allele has been positively selected in some human populations owing to its effect on skeletal muscle metabolism.