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Yara Bou Saada Vlada Zakharova Boris Chernyak Carla Dib Gilles Carnac Svetlana Dokudovskaya Yegor S. Vassetzky 《Cellular and molecular life sciences : CMLS》2017,74(19):3439-3449
Skeletal muscle is a highly oxygen-consuming tissue that ensures body support and movement, as well as nutrient and temperature regulation. DNA damage induced by reactive oxygen species is present in muscles and tends to accumulate with age. Here, we present a summary of data obtained on DNA damage and its implication in muscle homeostasis, myogenic differentiation and neuromuscular disorders. Controlled and transient DNA damage appears to be essential for muscular homeostasis and differentiation while uncontrolled and chronic DNA damage negatively affects muscle health. 相似文献
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