首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   36篇
  免费   0篇
系统科学   1篇
现状及发展   5篇
研究方法   2篇
综合类   25篇
自然研究   3篇
  2019年   1篇
  2011年   5篇
  2009年   1篇
  2007年   4篇
  2006年   1篇
  2005年   3篇
  2004年   4篇
  2002年   2篇
  2000年   1篇
  1988年   1篇
  1980年   1篇
  1974年   1篇
  1973年   1篇
  1972年   2篇
  1971年   1篇
  1970年   4篇
  1969年   2篇
  1967年   1篇
排序方式: 共有36条查询结果,搜索用时 15 毫秒
1.
The remarkable diversity, glycosylation and conformational flexibility of the human immunodeficiency virus type 1 (HIV-1) envelope (Env), including substantial rearrangement of the gp120 glycoprotein upon binding the CD4 receptor, allow it to evade antibody-mediated neutralization. Despite this complexity, the HIV-1 Env must retain conserved determinants that mediate CD4 binding. To evaluate how these determinants might provide opportunities for antibody recognition, we created variants of gp120 stabilized in the CD4-bound state, assessed binding of CD4 and of receptor-binding-site antibodies, and determined the structure at 2.3 A resolution of the broadly neutralizing antibody b12 in complex with gp120. b12 binds to a conformationally invariant surface that overlaps a distinct subset of the CD4-binding site. This surface is involved in the metastable attachment of CD4, before the gp120 rearrangement required for stable engagement. A site of vulnerability, related to a functional requirement for efficient association with CD4, can therefore be targeted by antibody to neutralize HIV-1.  相似文献   
2.
3.
The potential use of smallpox as a biological weapon has led to the production and stockpiling of smallpox vaccine and the immunization of some healthcare workers. Another public health goal is the licensing of a safer vaccine that could benefit the millions of people advised not to take the current one because they or their contacts have increased susceptibility to severe vaccine side effects. As vaccines can no longer be tested for their ability to prevent smallpox, licensing will necessarily include comparative immunogenicity and protection studies in non-human primates. Here we compare the highly attenuated modified vaccinia virus Ankara (MVA) with the licensed Dryvax vaccine in a monkey model. After two doses of MVA or one dose of MVA followed by Dryvax, antibody binding and neutralizing titres and T-cell responses were equivalent or higher than those induced by Dryvax alone. After challenge with monkeypox virus, unimmunized animals developed more than 500 pustular skin lesions and became gravely ill or died, whereas vaccinated animals were healthy and asymptomatic, except for a small number of transient skin lesions in animals immunized only with MVA.  相似文献   
4.
5.
6.
Daily periodicity of susceptibility of mice to pneumococcal infection   总被引:1,自引:0,他引:1  
  相似文献   
7.
Evidence for energy-dependent accumulation of paraquat into rat lung   总被引:8,自引:0,他引:8  
M S Rose  L L Smith  I Wyatt 《Nature》1974,252(5481):314-315
  相似文献   
8.
9.
本通过对几种拆分手性药物的方法的列举,比较几种方法,详细介绍了几种方法的特点,以及它们的不同作用。各个方法中又列出了不同的线索,根据这些线索来研究这几种拆分的方法,它们的优缺点以及针对这些缺点的解决方法,最后给出了几个典型的用该方法的实验,以辨别它们的效用。  相似文献   
10.
A pseudoknotted RNA oligonucleotide   总被引:18,自引:0,他引:18  
J D Puglisi  J R Wyatt  I Tinoco 《Nature》1988,331(6153):283-286
  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号