Effect of adrenalectomy and dexamethasone treatment on the monoamine oxidase activity in the thyroid gland of the rat

Summary Adrenalectomy increased MAO activity in the thyroid gland of rats. The administration (200 g/100 g daily for 7 days) to adrenalectomized rats decreased MAO activity below levels of intact controls.     

Hyperpolarization by cyclic AMP (activation of diphosphoinositide kinase)

Zusammenfassung In-vitro-und In-vivo-Versuche beweisen, dass ein molekulärer Mechanismus für das Zustandekommen der Membran-Hyperpolarisation verantwortlich ist.

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Presented in part at the Annual Meeting of the Biophysical Society, Toronto, Canada, February 1972.     

A cholinergic modulator.

Soluble proteins obtained from presynaptic cholinergic vesicles have been tested regarding their effects to modify postsynaptic spike generation. The results suggest that these proteins (or derivatives, incl. glycopeptides) may act as modulators in increasing the effectiveness and duration of postsynaptic spike generation. They may partake in generation of homosynaptic (posttetanic) potentiation.     

Depolarization by acetylcholine (ACH activation of triphosphoinositide phosphomonoesterase

Zusammenfassung Azetylcholin scheint die postsynaptische Depolarisierung durch Aktivierung von TPIPM (Triphosphoinositid Phosphomonoesterase) herbeizuführen und der spezifische, nikotinartige Azetylcholin-Rezeptor scheint dabei die regulatorische Untereinheit von TPIPM zu sein. Die Verbindung von Azetylcholin mit TPIPM setzt eine katalytische Untereinheit frei, die Triphosphoinositid in Diphosphoinositid umwandelt und zur Depolarisierung führt.

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Presented in part at the Annual Meeting of the Biophysical Society, Toronto, Canada, February 1972.