排序方式: 共有27条查询结果,搜索用时 31 毫秒
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Victor M. Guerrero 《Journal of forecasting》1993,12(1):37-48
This paper presents some procedures aimed at helping an applied time-series analyst in the use of power transformations. Two methods are proposed for selecting a variance-stabilizing transformation and another for bias-reduction of the forecast in the original scale. Since these methods are essentially model-independent, they can be employed with practically any type of time-series model. Some comparisons are made with other methods currently available and it is shown that those proposed here are either easier to apply or are more general, with a performance similar to or better than other competing procedures. 相似文献
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Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype 总被引:2,自引:0,他引:2
Jaillon O Aury JM Brunet F Petit JL Stange-Thomann N Mauceli E Bouneau L Fischer C Ozouf-Costaz C Bernot A Nicaud S Jaffe D Fisher S Lutfalla G Dossat C Segurens B Dasilva C Salanoubat M Levy M Boudet N Castellano S Anthouard V Jubin C Castelli V Katinka M Vacherie B Biémont C Skalli Z Cattolico L Poulain J De Berardinis V Cruaud C Duprat S Brottier P Coutanceau JP Gouzy J Parra G Lardier G Chapple C McKernan KJ McEwan P Bosak S Kellis M Volff JN Guigó R Zody MC Mesirov J Lindblad-Toh K 《Nature》2004,431(7011):946-957
Tetraodon nigroviridis is a freshwater puffer fish with the smallest known vertebrate genome. Here, we report a draft genome sequence with long-range linkage and substantial anchoring to the 21 Tetraodon chromosomes. Genome analysis provides a greatly improved fish gene catalogue, including identifying key genes previously thought to be absent in fish. Comparison with other vertebrates and a urochordate indicates that fish proteins have diverged markedly faster than their mammalian homologues. Comparison with the human genome suggests approximately 900 previously unannotated human genes. Analysis of the Tetraodon and human genomes shows that whole-genome duplication occurred in the teleost fish lineage, subsequent to its divergence from mammals. The analysis also makes it possible to infer the basic structure of the ancestral bony vertebrate genome, which was composed of 12 chromosomes, and to reconstruct much of the evolutionary history of ancient and recent chromosome rearrangements leading to the modern human karyotype. 相似文献
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Regot S Macia J Conde N Furukawa K Kjellén J Peeters T Hohmann S de Nadal E Posas F Solé R 《Nature》2011,469(7329):207-211
Ongoing efforts within synthetic and systems biology have been directed towards the building of artificial computational devices using engineered biological units as basic building blocks. Such efforts, inspired in the standard design of electronic circuits, are limited by the difficulties arising from wiring the basic computational units (logic gates) through the appropriate connections, each one to be implemented by a different molecule. Here, we show that there is a logically different form of implementing complex Boolean logic computations that reduces wiring constraints thanks to a redundant distribution of the desired output among engineered cells. A practical implementation is presented using a library of engineered yeast cells, which can be combined in multiple ways. Each construct defines a logic function and combining cells and their connections allow building more complex synthetic devices. As a proof of principle, we have implemented many logic functions by using just a few engineered cells. Of note, small modifications and combination of those cells allowed for implementing more complex circuits such as a multiplexer or a 1-bit adder with carry, showing the great potential for re-utilization of small parts of the circuit. Our results support the approach of using cellular consortia as an efficient way of engineering complex tasks not easily solvable using single-cell implementations. 相似文献
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Jacquemont S Reymond A Zufferey F Harewood L Walters RG Kutalik Z Martinet D Shen Y Valsesia A Beckmann ND Thorleifsson G Belfiore M Bouquillon S Campion D de Leeuw N de Vries BB Esko T Fernandez BA Fernández-Aranda F Fernández-Real JM Gratacòs M Guilmatre A Hoyer J Jarvelin MR Kooy RF Kurg A Le Caignec C Männik K Platt OS Sanlaville D Van Haelst MM Villatoro Gomez S Walha F Wu BL Yu Y Aboura A Addor MC Alembik Y Antonarakis SE Arveiler B Barth M Bednarek N Béna F Bergmann S Beri M Bernardini L 《Nature》2011,478(7367):97-102
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根据交直流混合微电网拓扑和并网运行特点,建立了接口换流器的数学模型,设计了基于滑模控制(sliding-mode con-trol, SMC)的接口换流器控制系统,并通过设计趋近律规定了滑模控制过程中系统在正常运动阶段的状态轨迹,保证滑模控制的品质。为证明控制系统在实际应用中的可行性,在dSPACE 1006 平台上建立了实验模型。仿真和实验结果表明,该控制系统可以提高接口换流器在不确定和非线性条件下的鲁棒性和快速响应性,保证微电网稳定运行。 相似文献
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P. J. Lardone A. Carrillo-Vico P. Molinero A. Rubio J. M. Guerrero 《Cellular and molecular life sciences : CMLS》2009,66(3):516-525
Human lymphocyte melatonin, through membrane and nuclear receptors binding, acts as an activator in IL-2 production. Antagonism
of membrane melatonin receptors using luzindole exacerbates the drop of the IL-2 production induced by PGE2 in peripheral blood mononuclear and Jurkat cells. This paper studies the melatonin membrane and nuclear receptors interplay
in PGE2-diminished IL-2 production. The decrease in IL-2 production after PGE2 and/or luzindole administration correlated with downregulation in the nuclear receptor RORα. We also highlighted a role of
cAMP in the pathway, because forskolin mimicked the effects of luzindole and/or PGE2 in the RORα expression. Finally, a significant RORα downregulation was observed in T cells permanently transfected with inducible
MT1 antisense. In conclusion, we show a novel connection between melatonin membrane receptor signalling and RORα expression,
opening a new way to understand melatonin regulation in lymphocyte physiology.
Received 23 September 2008; received after revision 19 November 2008; accepted 21 November 2008 相似文献
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Víctor M. Guerrero 《Journal of forecasting》1989,8(3):215-229
An optimal univariate forecast, based on historical and additional information about the future, is obtained in this paper. Its statistical properties, as well as some inferential procedures derived from it, are indicated. Two main situations are considered explicitly: (1) when the additional information imposes a constraint to be fulfilled exactly by the forecasts and (2) when the information is only a conjecture about the future values of the series or a forecast from an alternative model. Theoretical and empirical illustrations are provided, and a unification of the existing methods is also attempted. 相似文献
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