排序方式: 共有24条查询结果,搜索用时 31 毫秒
1.
M. Schlesinger N. Grossowicz N. Lichtenstein 《Cellular and molecular life sciences : CMLS》1969,25(1):14-15
Résumé L'administration i.p. de la carbobenzoxy-l-asparagine a retardé la croissance des greffes s.c. d'un lymphosarcome de souris, sensitif à l'action de l'l-asparaginase. L'apparition des tumeurs a été retardée, la période de survie a été prolongée et le poids des tumeurs réduit d'une faÇon significative chez les animaux traités. Le mécanisme de l'inhibition des tumeurs cst considéré. 相似文献
2.
Spontaneous occurrence of autoantibodies cytotoxic to thymus cells in the sera of mice of the 129 strain 总被引:4,自引:0,他引:4
M Schlesinger 《Nature》1965,207(995):429-430
3.
Schlesinger Y Straussman R Keshet I Farkash S Hecht M Zimmerman J Eden E Yakhini Z Ben-Shushan E Reubinoff BE Bergman Y Simon I Cedar H 《Nature genetics》2007,39(2):232-236
Many genes associated with CpG islands undergo de novo methylation in cancer. Studies have suggested that the pattern of this modification may be partially determined by an instructive mechanism that recognizes specifically marked regions of the genome. Using chromatin immunoprecipitation analysis, here we show that genes methylated in cancer cells are specifically packaged with nucleosomes containing histone H3 trimethylated on Lys27. This chromatin mark is established on these unmethylated CpG island genes early in development and then maintained in differentiated cell types by the presence of an EZH2-containing Polycomb complex. In cancer cells, as opposed to normal cells, the presence of this complex brings about the recruitment of DNA methyl transferases, leading to de novo methylation. These results suggest that tumor-specific targeting of de novo methylation is pre-programmed by an established epigenetic system that normally has a role in marking embryonic genes for repression. 相似文献
4.
A hexadecapeptide corresponding to positions 59--74 of ubiquitin was synthesized and purified. The peptide was characterized by its mobility in TLC and electrophoresis, amino acid sequence and composition, and molar rotation. The peptide possessed approximately 40% activity compared with native ubiquitin in each of 3 biological assays in vitro: a) thymocyte induction, b) B cell induction and c) elevation of intracellular cyclic AMP levels in sarcoma 180 cells. 相似文献
5.
Y. Leshem Hadassah Schlesinger Rina Peely 《Cellular and molecular life sciences : CMLS》1976,32(5):590-591
Summary Either by direct GA supply or by release of glycosidic bound GA, pollination causes partial opening of double-stranded DNA in somatic maize kernel tissues, as evidenced by increased Tm profiles. This phenomenon is associated with enhanced RNA and protein production.Acknowledgments: The authors wish to thank Dr.Y. Wurzburger for her aid and advice in extraction and biossay procedure. This research was financed by a grant from the Bar-Ilan Research Council. 相似文献
6.
Anti-theta antibodies for detecting thymus-dependent lymphocytes in the immune response of mice to SRBC 总被引:9,自引:0,他引:9
M Schlesinger 《Nature》1970,226(5252):1254-1256
7.
D. H. Schlesinger J. D. Capra I. L. Schwartz R. Walter 《Cellular and molecular life sciences : CMLS》1971,27(2):213-213
Zusammenfassung Durch Spaltung mit CNBr wurde gezeigt, dass Neurophysin II aus Rinderhypophyse nur eine Methionin-Einheit enthält und dass die N-terminale Sequenz Ala-Met ist.
This work was supported by NIH Grants No. AM-13567, No. AM-10080, by NSF Grant No. GB-17046 and by the City University of New York. The authors are indebted to Dr.L. Abrash for helpful discussion and MissM. Wahrenburg and Mr.V. S. Sapirstein for the assays.
Predoctoral fellow of the Department of Physiology. 相似文献
This work was supported by NIH Grants No. AM-13567, No. AM-10080, by NSF Grant No. GB-17046 and by the City University of New York. The authors are indebted to Dr.L. Abrash for helpful discussion and MissM. Wahrenburg and Mr.V. S. Sapirstein for the assays.
Predoctoral fellow of the Department of Physiology. 相似文献
8.
D. H. Schlesinger G. Goldstein Margrit P. Scheid M. Bitensky 《Cellular and molecular life sciences : CMLS》1978,34(6):703-704
Summary A hexadecapeptide corresponding to positions 59–74 of ubiquitin was synthesized and purified. The peptide was characterized by its mobility in TLC and electrophoresis, amino acid sequence and composition, and molar rotation. The peptide possessed approximately 40% activity compared with native ubiquitin in each of 3 biological assays in vitro: a) thymocyte induction, b) B cell induction and c) elevation of intracellular cyclic AMP levels in sarcoma 180 cells.Acknowledgments. We thank Dr Geoffrey Tregear for helpful suggestions for the synthesis strategy, Dr Jim Burton for guidance with the methods for establishing peptide purity, and Ronald King, Miriam Miller, Jeanette Dilley and Linda Townley for excellent technical assistance. This work was supported by U.S. Public Health Service Grants CA-08748, CA-16889, CA-08415, CA-17085 and AI-12487, and by NCI Contract CB-53868. 相似文献
9.
<正>作为一门组织完善的科学学科,生态学已迈入它的第二个世纪:生态学通过大量的实验和丰富的观察,让人类对自然界的运行规律有了基本的理解。今天,环境科学家拥有一系列强有力的工具和技术来测量和监督环境,并解读一大堆各种各样的数据。然而,尽管新信息海量般地涌现,生态学家们却常常无法将他们的知识有效地转化给公众和政策制定者。除非生态科学的发现能 相似文献
10.
Landscape of transcription in human cells 总被引:3,自引:0,他引:3
S Djebali CA Davis A Merkel A Dobin T Lassmann A Mortazavi A Tanzer J Lagarde W Lin F Schlesinger C Xue GK Marinov J Khatun BA Williams C Zaleski J Rozowsky M Röder F Kokocinski RF Abdelhamid T Alioto I Antoshechkin MT Baer NS Bar P Batut K Bell I Bell S Chakrabortty X Chen J Chrast J Curado T Derrien J Drenkow E Dumais J Dumais R Duttagupta E Falconnet M Fastuca K Fejes-Toth P Ferreira S Foissac MJ Fullwood H Gao D Gonzalez A Gordon H Gunawardena C Howald S Jha R Johnson P Kapranov B King 《Nature》2012,489(7414):101-108
Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations are also poorly understood. Because RNA represents the direct output of the genetic information encoded by genomes and a significant proportion of a cell's regulatory capabilities are focused on its synthesis, processing, transport, modification and translation, the generation of such a catalogue is crucial for understanding genome function. Here we report evidence that three-quarters of the human genome is capable of being transcribed, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs. These observations, taken together, prompt a redefinition of the concept of a gene. 相似文献