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Amaiden MR Santander VS Monesterolo NE Campetelli AN Rivelli JF Previtali G Arce CA Casale CH 《Cellular and molecular life sciences : CMLS》2011,68(10):1755-1768
The presence of tubulin in human erythrocytes was demonstrated using five different antibodies. Tubulin was distributed among
three operationally distinguishable pools: membrane, sedimentable structure and soluble fraction. It is known that in erythrocytes
from hypertensive subjects (HS), the Na+, K+-ATPase (NKA) activity is partially inhibited as compared with erythrocytes from normal subjects (NS). In erythrocytes from
HS the membrane tubulin pool is increased by ~150%. NKA was found to be forming a complex with acetylated tubulin that results
in inhibition of enzymes. This complex was also increased in erythrocytes from HS. Treatment of erythrocytes from HS with
nocodazol caused a decrease of acetylated tubulin in the membrane and stimulation of NKA activity, whereas taxol treatment
on erythrocytes from NS had the opposite effect. These results suggest that, in erythrocytes from HS, tubulin was translocated
to the membrane, where it associated with NKA with the consequent enzyme inhibition. 相似文献
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