Die Aktivität der alkalischen Phosphatase im Rattenharn nach Mastzelldegranulierung

Summary Alkaline phosphatase activity was determined in rat urine under normal conditions (80 animals) and following mast cell depletion (30 animals). A statistically significant increase in urinary APA was found after administration of the mast-cell depleting compound 48/80. This fourfold increase over normal activity is due to renal changes caused by shock.     

Die alkalische Phosphatase-Aktivität des Ratten-serums nach anaphylaktoidem Schock

Summary At seven different intervals after the elicitation of anaphylactoid shock (compound 48/80), determinations of alkaline phosphatase (AP) activity were carried out in rat serum. No significant increase could be detected. These findings exclude extrarenal factors as the cause for increased AP-activity in urine following anaphylactoid shock.     

Die Leucinaminopeptidaseaktivität des Rattenharnes nach Verabreichung einer mastzellerschöpfenden Substanz

Summary LAP activity was determined in rat urine under normal conditions and following mast cell depletion by compound 48/80. A statistically significant increase in urinary LAP activity is found after administration of compound 48/80. This increase is due to mast cell depletion and the resulting anaphylactoid reaction.     

Hydroxyprolin-Ausscheidung im Rattenharn nach Injektion von Schlangengift

Summary In rats, a statistically significant increase in hydroxyproline excretion occurs following injection of crotalus toxin (Agkistrodon piscivorus Lacépède). The significance of this finding is briefly discussed.     

Antiandrogenic potency of drugs,evaluated by urinary enzyme excretion technique

Zusammenfassung Bei Ratten konnte nach der Verabreichung von Nitrotrifluoromethylisobutyranilid, einer neuen antiandrogen wirksamen Substanz, ein signifikanter Abfall der sauren Phosphatase-Aktivität im Harn festgestellt werden. Andere Harnenzymaktivitäten (alkalische Phosphatase, «Leucinaminopeptidase») blieben unbeeinflusst. Die Aktivität der sauren Phosphatase im Serum zeigte nach zweiwöchiger Verabreichung des Antiandrogens keine signifikante Veränderung. Die Bestimmung der sauren Phosphatase-Aktivität im Harn eignet sich demnach zum einfachen «Screening» antiandrogener Wirkungen.     

Light interference from single atoms and their mirror images

A single atom emitting single photons is a fundamental source of light. But the characteristics of this light depend strongly on the environment of the atom. For example, if an atom is placed between two mirrors, both the total rate and the spectral composition of the spontaneous emission can be modified. Such effects have been observed using various systems: molecules deposited on mirrors, dye molecules in an optical cavity, an atom beam traversing a two-mirror optical resonator, single atoms traversing a microwave cavity and a single trapped electron. A related and equally fundamental phenomenon is the optical interaction between two atoms of the same kind when their separation is comparable to their emission wavelength. In this situation, light emitted by one atom may be reabsorbed by the other, leading to cooperative processes in the emission. Here we observe these phenomena with high visibility by using one or two single atom(s), a collimating lens and a mirror, and by recording the individual photons scattered by the atom(s). Our experiments highlight the intimate connection between one-atom and two-atom effects, and allow their continuous observation using the same apparatus.     

Inhibition of ultraviolet-induced hydroxyproline formation in human dermal collagen

Zusammenfassung In Gegenwart des Chelatbildners Dipyridyl ist die unter der Einwirkung von UV-Bestrahlung eintretende Oxydation von Prolin zu Hydroxyprolin gehemmt, wie hier am Beispiel von neutralsalzlöslichem dermalem Kollagen des Menschen gezeigt werden konnte. Die unter den gleichen Bedingungen einsetzende Degradation der primären Kollagenketten wird jedoch durch die Gegenwart von Dipyridyl nicht gestört, so dass ein direkter Zusammenhang zwischen den beiden Effekten ausgeschlossen werden kann.