Variation in FTO contributes to childhood obesity and severe adult obesity

We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.     

“绿满园”对红蜘蛛的生物活性及对三种蜘蛛的毒性测定

采用玻片粘胶浸渍法测定“绿满园”水剂对柑桔红蜘蛛Panonychus citri的生物活性,同时采用浸渍法测定“绿满园”水剂对三突花蛛、斜纹猫蛛和拟环纹豹蛛3种蜘蛛的毒力.结果表明,16％“绿满园”水剂18.75倍稀释液对红蜘蛛毒性最强,处理72 h后红蜘蛛死亡率可达99.0％.受药48 h后,“绿满园”对红蜘蛛的毒力...     

Effect of a mitogenic concentration on membrane glycoconjugates of human lymphocytes

Periodate oxidation of human peripheral blood lymphocytes followed by reduction with 3H labelled sodium borohydride and acidic hydrolysis generates N-AN 7, glycerol and propane 1-2 diol. This indicates that sialyl, fucosyl and probably galactosyl residues are oxidized by periodate. Neuraminidase-treated lymphocytes exhibit decreased N-AN 7 levels, increased N-AN 8 levels and increased glycerol levels. Such results were neither found with mouse splenocytes nor with calf lymph node cells.     

The importance of the terminal hemi-acetal group for the ionophoric properties of nigericin

Summary Opening of the terminal hemi-acetal in dihydronigericin drastically reduces the ionophoric properties of nigericin and dehydroxymethylnigericin with 6 intact heterocycles. This is shown by 2 complementary methods, first with a liquid membrane electrode system, secondly by testing their ionophoric activities in rat liver mitochondria.Acknowledgments. The authors are indebted to Mrs G. Kergomard for her invaluable assistance in the isolement of nigericin and to Prof. A. Kergomard for his encouragements.     

Changes in mammary tissue lipid metabolism in the goats during the first 2 months of lactation]

5 French Alpine Goats were studied after normal or premature parturition. Mammary tissue acetyl-C oA carboxylase, glucose-6-phosphate dehydrogenase, malic enzyme and lipoprotein lipase (LPL) activities varied in parallel with milk fat secretion from the 3rd to the 9th week of lactation. Variations of mammary LPL activity and of long chain fatty acid secretion were positively highly correlated during that period. In goats with normal parturition, lipogenic activities seemed to reach a maximum level shortly after parturition. There was a positive correlation between mammary Ll activities and plasma non esterified fatty acid contents, possibly reflecting a relationship between adipose tissue mobilisation and mammary metabolism.     

Effet du fractionnement de dose sur la survie de bourgeons axillaires etde cellules isolées de liseron irradiés aux rayons gamma

Summary Split-dose recovery has been shown on bindweed (Calystegia=Convolvulus sepium [L.] R. Br.) nodes and isolated single cells in aseptic culture. Recovery from sublethal damage occurs within 2 h.

---

---

Nous remercions vivement M^lle L. Rossini qui nous a transmis la technique de culture de cellules de liseron. Les irradiations ont été réalisées grâce à l'obligeance de M^lle E. Moustacchi.