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Gandhi TK Zhong J Mathivanan S Karthick L Chandrika KN Mohan SS Sharma S Pinkert S Nagaraju S Periaswamy B Mishra G Nandakumar K Shen B Deshpande N Nayak R Sarker M Boeke JD Parmigiani G Schultz J Bader JS Pandey A 《Nature genetics》2006,38(3):285-293
We present the first analysis of the human proteome with regard to interactions between proteins. We also compare the human interactome with the available interaction datasets from yeast (Saccharomyces cerevisiae), worm (Caenorhabditis elegans) and fly (Drosophila melanogaster). Of >70,000 binary interactions, only 42 were common to human, worm and fly, and only 16 were common to all four datasets. An additional 36 interactions were common to fly and worm but were not observed in humans, although a coimmunoprecipitation assay showed that 9 of the interactions do occur in humans. A re-examination of the connectivity of essential genes in yeast and humans indicated that the available data do not support the presumption that the number of interaction partners can accurately predict whether a gene is essential. Finally, we found that proteins encoded by genes mutated in inherited genetic disorders are likely to interact with proteins known to cause similar disorders, suggesting the existence of disease subnetworks. The human interaction map constructed from our analysis should facilitate an integrative systems biology approach to elucidating the cellular networks that contribute to health and disease states. 相似文献
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OPTIMAL MAINTENANCE AND REPLACEMENT OF EXTRACTION MACHINERY 总被引:1,自引:1,他引:0
This paper considers a problem of optimal preventive maintenance and replacement schedule of equipment devoted to extracting resources from known deposits. Typical examples are oil drills, mine shovels, etc. At most one replacement of the existing machinery by a new one is allowed. The problem is formulated as an optimal control problem subject to the state constraint that the remaining deposit at any given time is nonnegative. We show that the optimal preventive maintenance, production rates, and the replacement and salvage times of the existing machinery and the new one, if required, can be obtained by solving sequentially a series of free-end-point optimal control problems. Moreover, an algorithm based on this result is developed and used to solve two illustrative examples. 相似文献
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Erratum to: J Syst Sci Syst Eng DOI: ./s--- The presentation of Table in the original version of this article contained a few typos. The corrected Table is given below. …… 《系统科学与系统工程学报(英文版)》2008,17(2):255-256
Erratum to: J Syst Sci Syst Eng
DOI: 10.1007/s11518-007-5058-2
The presentation of Table 2 in the original version of this article contained a few typos. The corrected Table 2 is given below. 相似文献
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R. S. Thakur Suresh C. Bagadia M. L. Sharma 《Cellular and molecular life sciences : CMLS》1978,34(2):158-159
Summary Evaluation of the hypotensive activity of dihydroxy coumarins and their congeners reveal that the naturally occurring dimethoxy coumarin Scoparone has maximal activity, more significant than L--methyl dopa. Structure activity relationship studies are reported with an attempt to offer a probable mechanism of action. 相似文献
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Summary The epiphyseal cartilage from new-born mouse was treated with collagenase in two ways: either before fixation or after glutaraldehyde fixation. The electron dense granules of the matrix were not seen in the micrographs of cartilage treated with collagenase before fixation. It is concluded that collagen plays a definite role in the formation of the granules at the time of tissue fixation and that the granules are fixation artifacts.Commonwealth Academic Staff Fellow. Permanent address: Department of Zoology, University of Poona, Poona 411007, India. 相似文献
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Suresh C. Goel 《Cellular and molecular life sciences : CMLS》1976,32(10):1331-1333
Summary Experiments show that osmotic gradient has a role in the absorption of water by the semi-cleidoic egg ofCalotes versicolor. The observations also indicate that in nature the eggs need to be laid in water-saturated soil and can easily withstand flooding but not dryness. 相似文献
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Barreto G Schäfer A Marhold J Stach D Swaminathan SK Handa V Döderlein G Maltry N Wu W Lyko F Niehrs C 《Nature》2007,445(7128):671-675
DNA methylation is an epigenetic modification that is essential for gene silencing and genome stability in many organisms. Although methyltransferases that promote DNA methylation are well characterized, the molecular mechanism underlying active DNA demethylation is poorly understood and controversial. Here we show that Gadd45a (growth arrest and DNA-damage-inducible protein 45 alpha), a nuclear protein involved in maintenance of genomic stability, DNA repair and suppression of cell growth, has a key role in active DNA demethylation. Gadd45a overexpression activates methylation-silenced reporter plasmids and promotes global DNA demethylation. Gadd45a knockdown silences gene expression and leads to DNA hypermethylation. During active demethylation of oct4 in Xenopus laevis oocytes, Gadd45a is specifically recruited to the site of demethylation. Active demethylation occurs by DNA repair and Gadd45a interacts with and requires the DNA repair endonuclease XPG. We conclude that Gadd45a relieves epigenetic gene silencing by promoting DNA repair, which erases methylation marks. 相似文献
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