Disparate Na+-requirement of taurocholate and indocyanine green uptake by isolated hepatocytes.

Uptake of both taurocholate and indocyanine green (ICG) by isolated rat hepatocytes was saturable and obeyed Michaelis-Menten kinetics. Only uptake of taurocholate exhibited Na+-dependence, a phenomenon compatible with active membrane transport. These findings suggest that the mechanisms responsible for hepatocellular uptake of bile acids and anionic dyes differ fundamentally.     

Formation of N-glucuronide of desmethylimipramine in the dog

Zusammenfassung Nach Verbreichung von Imipramin oder Desmethylimipramin bilden Hunde neben den bekannten Metaboliten Konjugate von Desmethylimipramin (und in kleineren Mengen von Desdimethylimipramin). Die Befunde sprechen für aliphatische N-Glukuronide und damit für einen bisher kaum beschriebenen Typus von Arzneimittelmetaboliten.

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Acknowledgment. We are indebted to the Swiss National Science Foundation for support and to Dr.R. Preisig for the use of facilities at the Institute of Clinical Pharmacology, University of Berne.     

Über die Änderung der Hydrolyse von Tetrachlorkohlenstoff durch Röntgenstrahlen bei Zugabe von Alkohol

Summary Hydrolysis of carbon tetrachloride in aqueous solutions by X-rays is changed quantitatively and qualitatively when alcohol is added to the solutions. This change is conform with a new theory of the actions of radiations published recently by one of the authors.     

Über den gegenwärtigen Stand des Hauptproblems der Strahlenbiologie

Summary Two possibilities for the action of radiations on biological objects are still remaining: the effect by radiation-hits and the action by photochemical or radiochemical effects. By means of irradiating well-known chemical «model-substances» one may be able to decide between these two possibilities and to understand the biological primary effect of radiations.Both of the theoretical perceptions are discussed and compared with the empirical facts. It is shown that in all well examinated cases of radiation effects upon biological elements or chemical systems, water or an other diluting is of essential importance. Radiation-energy is conducted from point of absorption to point of action by means of electronic transport or diffusion. Diffusion seems much more probable in biological systems.     

Disparate Na+-requirement of taurocholate and indocyanine green uptake by isolated hepatocytes

Summary Uptake of both taurocholate and indocyanine green (ICG) by isolated rat hepatocytes was saturable and obeyed Michaelis-Menten kinetics. Only uptake of taurocholate exhibited Na⁺-dependence, a phenomenon compatible with active membrane transport. These findings suggest that the mechanisms responsible for hepatocellular uptake of bile acids and anionic dyes differ fundamentally.This work was supported by the Swiss National Science Foundation.The authors thank Mr Th. Weber for technical assistance.     

Über den Temperatureinfluß bei der Strahlenoxydation von Ferrosulfat

Summary Oxidation of ferric sulphate in a concentration of about 0,002 mols per litre by means of- and-radiations shows no dependence from temperature between 4 and 54 degrees Celsius. Frozen solutions are not oxidized by radiations. Therefore reaction is only possible, when water molecules have free movement. The probability of energy-conduction for the used concentration is not changed by rising temperature for 50 degrees.     

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