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Effects were examined of atropine, diazepam, pethidene, promethazine, scopolamine, omnopon and papaverine on basal and noradrenaline-stimulated lipolysis in rat isolated fat cells and on rat adipose tissue cyclic AMP phosphodiesterase activity. Papaverine at high concentration (1 mM) inhibited both basal and hormone-stimulated lipolysis, whereas diazepam enhanced basal lipolysis. At a 'clinical dose', omnopon increased both basal and noradrenaline-stimulated lipolysis. Adipose tissue cAMP phosphodiesterase activity was strongly inhibited by 1 mM diazepam, papaverine, promethazine and omnopon (280 microgram ml-1). Lack of enhancement of lipolysis by the established cAMP phosphodiesterase antagonist papaverine, is compatible with simultaneous inhibition also of adipose adenyl cyclase. Diazepam-stimulated lipolysis is compatible with its phosphodiesterase inhibitory activity. It is proposed that papaverine-containing omnopon may offer some survival advantages during surgical stress by facilitating a caloric supply. 相似文献
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P. B. Curtis-Prior M. Jenner Y-H. Chan I. McColl 《Cellular and molecular life sciences : CMLS》1979,35(11):1430-1431
Summary Effects were examined of atropine, diazepam, pethidene, promethazine, scopolamine, omnopon and papaverine on basal and noradrenaline-stimulated lipolysis in rat isolated fat cells and on rat adipose tissue cyclic AMP phosphodiesterase activity. Papaverine at high concentration (1 mM) inhibited both basal and hormone-stimulated lipolysis, whereas diazepam enhanced basal lipolysis. At a clinical dose, omnopon increased both basal and noradrenaline-stimulated lipolysis. Adipose tissue cAMP phosphodiesterase activity was strongly inhibited by 1 mM diazepam, papaverine, promethazine and omnopon (280 g ml–1). Lack of enhancement of lipolysis by the established cAMP phosphodiesterase antagonist papaverine, is compartible with simultaneous inhibition also of adipose adenyl cyclase. Diazepam-stimulated lipolysis is compatible with its phosphodiesterase inhibitory activity. It is proposed that papaverine-containing omnopon may offer some survival advantages during surgical stress by facilitating a caloric supply.The authours are grateful to Dr D. C. Williams for his continued support and encouragement. 相似文献
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Mechanism of intestinal absorption in man 总被引:3,自引:0,他引:3
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Interleukin-1 polymorphisms associated with increased risk of gastric cancer 总被引:190,自引:0,他引:190
El-Omar EM Carrington M Chow WH McColl KE Bream JH Young HA Herrera J Lissowska J Yuan CC Rothman N Lanyon G Martin M Fraumeni JF Rabkin CS 《Nature》2000,404(6776):398-402
Helicobacter pylori infection is associated with a variety of clinical outcomes including gastric cancer and duodenal ulcer disease. The reasons for this variation are not clear, but the gastric physiological response is influenced by the severity and anatomical distribution of gastritis induced by H. pylori. Thus, individuals with gastritis predominantly localized to the antrum retain normal (or even high) acid secretion, whereas individuals with extensive corpus gastritis develop hypochlorhydria and gastric atrophy, which are presumptive precursors of gastric cancer. Here we report that interleukin-1 gene cluster polymorphisms suspected of enhancing production of interleukin-1-beta are associated with an increased risk of both hypochlorhydria induced by H. pylori and gastric cancer. Two of these polymorphism are in near-complete linkage disequilibrium and one is a TATA-box polymorphism that markedly affects DNA-protein interactions in vitro. The association with disease may be explained by the biological properties of interleukin-1-beta, which is an important pro-inflammatory cytokine and a powerful inhibitor of gastric acid secretion. Host genetic factors that affect interleukin-1-beta may determine why some individuals infected with H. pylori develop gastric cancer while others do not. 相似文献
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Drago J McColl CD Horne MK Finkelstein DI Ross SA 《Cellular and molecular life sciences : CMLS》2003,60(7):1267-1280
Neuronal nicotinic acetylcholine receptors are ligand-gated ion channels that subserve a
range of functions in the brain and peripheral nervous system. They are pentamers variously composed
of (2– 10) and subunits
( 2– 4). Pharmacological and ligand-binding
studies have shown that the different subunits vary in their distribution and channel properties, but
precise delineation of the in vivo function of individual subunits has been hampered by lack of
subunit-specific antagonists. The development of transgenic mice with targeted deletions
of specific subunits (knockout mice) or mutations in critical receptor domains (knockin mice)
has extended understanding of nicotinic receptors, revealing that some subunits are necessary for
viability, whereas others mediate modulatory effects on learning and memory, locomotion,
anxiety, nociception, dopaminergic neurotransmission, seizure threshold, development of the visual
system and autonomic function. In some cases, studies of transgenic mice have confirmed expectations
derived from pharmacological and expression studies, but in other cases, compensation by related
subunits has revealed a degree of functional redundancy not predicted by previous approaches.Received 19 September 2002; received after revision 12 November 2002; accepted 11 December 2002 相似文献
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Serdar Neslihanoglu Vasilios Sogiakas John H. McColl Duncan Lee 《Journal of forecasting》2017,36(8):867-897
This paper examines the forecasting ability of the nonlinear specifications of the market model. We propose a conditional two‐moment market model with a time‐varying systematic covariance (beta) risk in the form of a mean reverting process of the state‐space model via the Kalman filter algorithm. In addition, we account for the systematic component of co‐skewness and co‐kurtosis by considering higher moments. The analysis is implemented using data from the stock indices of several developed and emerging stock markets. The empirical findings favour the time‐varying market model approaches, which outperform linear model specifications both in terms of model fit and predictability. Precisely, higher moments are necessary for datasets that involve structural changes and/or market inefficiencies which are common in most of the emerging stock markets. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
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Résumé Des malformations squelettiques: dyssymphyses sternales, des anomalies vertébrales, crâniennes et costales ont été observées, chez des rejetons de rates de souche Sprague-Dawley, traitées avec de la thalidomide, du phénobarbital, de la méthaqualone et du glutéthimide pendant toute la période de gestation. 相似文献
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