Variations in cardiac noradrenaline content during sodium loading in hypertension prone and resistant rats

Summary The cardiac catecholamine content of Sabra rats and their 2 genetically derived substrains, hypertension prone and resistant rats, was studied by high pressure liquid chromatography and electrochemical detection. Both in the control period and after sodium and DOCA administration the cardiac noradrenaline level is higher in hypertension resistant rats than in Sabra rats, and also higher than in hypertension prone rats. This finding suggests that a reduction of the cardiac sympathetic nervous tone is involved in the genetic resistance to sodium.     

Demonstration of specific receptors for angiotensin III in rat adrenal glands]

Distinct and specific binding sites for 3H-angiotensin II (A II) AND 3H-angiotensin III (A III) have been demonstrated in Rat adrenal gland preparations. A III binding sites have the highest affinity (KD29C1-2.10(-10)M) for the 2-8 heptapeptide. This suggests the possibility of a separate and distinct physiological role for the 2-8 heptapeptide, mediated via such A III binding sites.     

Identification of intracellular particles of pesticides in ciliate protozoa by Raman microprobe

Summary A Raman microprobe technique was used for the identification of intracellular particles of a pesticide added to a culture of the ciliate protozoanColpidium campylum. 2 methods, a wet and a dry, can be used for sample preparation. In both cases it was possible to find characteristic lines of 2 pollutants: 4,4-dichlorodiphenyl and-endosulfan. Some technical problems were encountered: the dry method causes drastic cellular alteration; the cell can move and go out of laser focus in the wet method.