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Madhuri Kalathur Silvia Baiguera Paolo Macchiarini 《Cellular and molecular life sciences : CMLS》2010,67(24):4185-4196
There are a variety of airway diseases with different clinical settings, which may extend from a surgical approach to total
organ replacement. Tissue engineering involves modifying cells or tissues in order to repair, regenerate, or replace tissue
in the body and seems to be a promising approach for airway replacement. The successful implantation of stem-cell-based tissue-engineered
trachea in a young woman with end-stage post-tuberculosis left main bronchus collapse serves as a prototype for the airway
tissue-engineered-based approach. The trachea indeed could represent a perfect model system to investigate the translational
aspects of tissue engineering, largely due to its low-oxygen needs. This review highlights the anatomy of the airways, the
various disease conditions that cause damage to the airways, elaborates on the essential components of the tissue-engineering
approach, and discusses the success of the revolutionary trachea transplantation approach. 相似文献
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Zusammenfassung Bei der karyologischen Analyse von Metaphasen in Knochenmark, Cornea und andern Geweben des indischen Meerschweinchens,Cavia porcellus (7 , 3 ) wurde festgestellt, dass drei männliche Individuen in einem autosomalen Chromosom heterozygot waren. Das Chromosom wird als Marker III bezeichnet. 相似文献
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