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JIAO Jiwen Qingdao Naval Submarine Academy Qingdao WU Haihua Hsin Ten Institute of International Economics Qingdao University Qingdao 《系统科学与系统工程学报(英文版)》1998,(3)
1ThoughtsontheModelingInliterature[1],wesetuptheinputoutputtableforperiodtontheassumptionthattheinputoutputrelationshipof“n... 相似文献
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Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis
Lee YC Kuo HC Chang JS Chang LY Huang LM Chen MR Liang CD Chi H Huang FY Lee ML Huang YC Hwang B Chiu NC Hwang KP Lee PC Chang LC Liu YM Chen YJ Chen CH;Taiwan Pediatric ID Alliance Chen YT Tsai FJ Wu JY 《Nature genetics》2012,44(5):522-525
To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10(-8)). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis. 相似文献
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Chiow KH Tan Y Chua RY Huang D Ng ML Torta F Wenk MR Wong SH 《Cellular and molecular life sciences : CMLS》2012,69(9):1505-1521
Since being introduced globally as aspirin in 1899, acetylsalicylic acid has been widely used as an analgesic, anti-inflammation,
anti-pyretic, and anti-thrombotic drug for years. Aspirin had been reported to down-regulate surface expression of CD40, CD80,
CD86, and MHCII in myeloid dendritic cells (DC), which played essential roles in regulating the immune system. We hypothesized
that the down-regulation of these surface membrane proteins is partly due to the ability of aspirin in regulating trafficking/sorting
of endocytosed surface membrane proteins. By using an established epidermoid carcinoma cell line (A-431), which overexpresses
the epidermal growth factor receptor (EGFR) and transferrin receptor (TfnR), we show that aspirin (1) reduces cell surface
expression of EGFR and (2) accumulates endocytosed-EGFR and -TfnR in the early/sorting endosome (ESE). Further elucidation
of the mechanism suggests that aspirin enhances recruitment of SNX3 and SNX5 to membranes and consistently, both SNX3 and
SNX5 play essential roles in the aspirin-mediated accumulation of endocytosed-TfnR at the ESE. This study sheds light on how
aspirin may down-regulate surface expression of EGFR by inhibiting/delaying the exit of endocytosed-EGFR from the ESE and
recycling of endocytosed-EGFR back to the cell surface. 相似文献
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An econometric model for exchange rate based on the behavior of dynamic international asset allocation is considered. The capital movement intensity index is constructed from the adjustment of a fully hedged international portfolio. Including this index as an additional explanatory variable helps to explain the fluctuation of the exchange rate and predict better than the competing random walk model. Supporting empirical evidence is found in Germany–USA, Japan–USA, Singapore–USA and Taiwan–USA exchange markets. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
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JIAO Jiwen Qingdao Naval Submarine Academy WU Haihua Hsin Ten Institute of International Economics Qingdao University WANG Hui Qingdao Naval Submarine Academy 《系统科学与系统工程学报(英文版)》1998,(2)
1IntroductionIntheeconomicdevelopmentofacountry,therearenormalytwoadjustingwaysoftheindustrialstructure,i.e.:incrementaladjus... 相似文献
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Noguera-Troise I Daly C Papadopoulos NJ Coetzee S Boland P Gale NW Lin HC Yancopoulos GD Thurston G 《Nature》2006,444(7122):1032-1037
Tumour growth requires accompanying expansion of the host vasculature, with tumour progression often correlated with vascular density. Vascular endothelial growth factor (VEGF) is the best-characterized inducer of tumour angiogenesis. We report that VEGF dynamically regulates tumour endothelial expression of Delta-like ligand 4 (Dll4), which was previously shown to be absolutely required for normal embryonic vascular development. To define Dll4 function in tumour angiogenesis, we manipulated this pathway in murine tumour models using several approaches. Here we show that blockade resulted in markedly increased tumour vascularity, associated with enhanced angiogenic sprouting and branching. Paradoxically, this increased vascularity was non-productive-as shown by poor perfusion and increased hypoxia, and most importantly, by decreased tumour growth-even for tumours resistant to anti-VEGF therapy. Thus, VEGF-induced Dll4 acts as a negative regulator of tumour angiogenesis; its blockade results in a striking uncoupling of tumour growth from vessel density, presenting a novel therapeutic approach even for tumours resistant to anti-VEGF therapies. 相似文献