排序方式: 共有4条查询结果,搜索用时 0 毫秒
1
1.
2.
Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse 总被引:24,自引:0,他引:24
Lindblad-Toh K Winchester E Daly MJ Wang DG Hirschhorn JN Laviolette JP Ardlie K Reich DE Robinson E Sklar P Shah N Thomas D Fan JB Gingeras T Warrington J Patil N Hudson TJ Lander ES 《Nature genetics》2000,24(4):381-386
Single-nucleotide polymorphisms (SNPs) have been the focus of much attention in human genetics because they are extremely abundant and well-suited for automated large-scale genotyping. Human SNPs, however, are less informative than other types of genetic markers (such as simple-sequence length polymorphisms or microsatellites) and thus more loci are required for mapping traits. SNPs offer similar advantages for experimental genetic organisms such as the mouse, but they entail no loss of informativeness because bi-allelic markers are fully informative in analysing crosses between inbred strains. Here we report a large-scale analysis of SNPs in the mouse genome. We characterized the rate of nucleotide polymorphism in eight mouse strains and identified a collection of 2,848 SNPs located in 1,755 sequence-tagged sites (STSs) using high-density oligonucleotide arrays. Three-quarters of these SNPs have been mapped on the mouse genome, providing a first-generation SNP map of the mouse. We have also developed a multiplex genotyping procedure by which a genome scan can be performed with only six genotyping reactions per animal. 相似文献
3.
The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction 总被引:5,自引:0,他引:5
Cannabinoids represent one of the most widely used hallucinogenic drugs and induce profound alterations in sensory perception
and emotional processing. Similarly, the dopamine (DA) neurotransmitter system is critical for the central processing of emotion
and motivation. Functional disturbances in either of these neurotransmitter systems are well-established correlates of the
psychopathological symptoms and behavioral manifestations observed in addiction and schizophrenia. Increasing evidence from
the anatomical, pharmacological and behavioral neuroscience fields points to complex functional interactions between these
receptor systems at the anatomical, pharmacological and neural systems levels. An important question relates to whether these
systems act in an orchestrated manner to produce the emotional processing and sensory perception deficits underlying addiction
and schizophrenia. This review describes evidence for functional neural interactions between cannabinoid and DA receptor systems
and how disturbances in this neural circuitry may underlie the aberrant emotional learning and processing observed in disorders
such as addiction and schizophrenia.
Received 20 January 2006; received after revision 14 March 2006; accepted 29 March 2006 相似文献
4.
碲锡铅(Pb1-xSnxTe)是一种禁带宽度可调的三元化合物半导体,用它不仅可制备814μm的高灵敏度的红外探测器,而且可以制备长波红外可调谐激光器. 相似文献
1