全文获取类型
收费全文 | 682篇 |
免费 | 3篇 |
国内免费 | 7篇 |
专业分类
系统科学 | 16篇 |
丛书文集 | 2篇 |
理论与方法论 | 6篇 |
现状及发展 | 91篇 |
研究方法 | 99篇 |
综合类 | 443篇 |
自然研究 | 35篇 |
出版年
2018年 | 5篇 |
2017年 | 6篇 |
2015年 | 7篇 |
2014年 | 6篇 |
2013年 | 4篇 |
2012年 | 56篇 |
2011年 | 91篇 |
2010年 | 11篇 |
2009年 | 12篇 |
2008年 | 43篇 |
2007年 | 46篇 |
2006年 | 46篇 |
2005年 | 59篇 |
2004年 | 37篇 |
2003年 | 36篇 |
2002年 | 41篇 |
2001年 | 17篇 |
2000年 | 9篇 |
1999年 | 8篇 |
1998年 | 4篇 |
1996年 | 4篇 |
1995年 | 3篇 |
1993年 | 5篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1989年 | 4篇 |
1988年 | 8篇 |
1987年 | 2篇 |
1986年 | 7篇 |
1985年 | 6篇 |
1984年 | 8篇 |
1983年 | 6篇 |
1982年 | 6篇 |
1981年 | 4篇 |
1979年 | 3篇 |
1977年 | 4篇 |
1976年 | 7篇 |
1975年 | 4篇 |
1974年 | 4篇 |
1973年 | 5篇 |
1972年 | 2篇 |
1971年 | 8篇 |
1970年 | 9篇 |
1968年 | 4篇 |
1967年 | 5篇 |
1966年 | 6篇 |
1965年 | 5篇 |
1961年 | 2篇 |
1958年 | 1篇 |
1957年 | 3篇 |
排序方式: 共有692条查询结果,搜索用时 15 毫秒
1.
基于SIMULINK的Fuzzy-PID控制器设计 总被引:1,自引:0,他引:1
设计了一种Fuzzy-PID控制算法,利用MATLAB的SIMULINK进行仿真研究,结果表明,该控制器具有较强的抗干扰能力和鲁棒性,有较好的动、静态控制精度. 相似文献
2.
3.
受到资讯媒体新科技影响 ,图书馆读者使用行为已从单一的馆藏利用 ,转为期望图书馆提供更多元化的服务 ;另外在财政紧缩 资源扩增 人力不足等因素下 ,图书馆提供各类型服务的运作模式也受到相当的冲击 ,图书馆为提供以读者为道向的服务 ,必需付出许多努力并改变服务哲学 ,因而图书馆馆员的专业知能发展要不断提升才能因应数位时代的环境改变 ,并提供读者一个优质的资讯服务 ,发挥图书馆LearningResourceCenter学习资源中心的角色 .本研究主要探讨图书馆如何在有限资源下 ,有系统地规划发展馆员专业知能 ,并且利用那一种方法可以最有效率、花费最少成本达到最大的馆员能力提升效果 ,根据文献探讨以及学习行为方法理论 ,提出一个适合发展馆员专业知能的模式 (Approachmodel) ,通过探讨逢甲大学图书馆的两个专案其馆员专业知能转变的历程 ,检视了此发展模式的成效 ,并提出未来该模式可再改进的方向及建议 相似文献
4.
5.
Anne Berna François Bernier Eric Chabrière Mikael Elias Ken Scott Andrew Suh 《Cellular and molecular life sciences : CMLS》2009,66(14):2205-2218
DING proteins, identified mainly by their eponymous N-terminal sequences, are ubiquitous in living organisms. Amongst bacteria,
they are common in pseudomonads, and have been characterised with respect to genetics and structure. They form part of a wider
family of phosphate-binding proteins, with emerging roles in phosphate acquisition and pathogenicity. Many DING proteins have
been isolated in eukaryotes, in which they have been associated with very diverse biological activities, often in the context
of possible signalling roles. Disease states in which DING proteins have been implicated include rheumatoid arthritis, lithiasis,
atherosclerosis, some tumours and tumour-associated cachexia, and bacterial and viral adherence. Complete genetic and structural
characterisation of eukaryotic DING genes and proteins is still lacking, though the phosphate-binding site seems to be conserved.
Whether as bacterial proteins related to bacterial pathogenicity, or as eukaryotic components of biochemical signalling systems,
DING proteins require further study.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
6.
Sato T Mushiake S Kato Y Sato K Sato M Takeda N Ozono K Miki K Kubo Y Tsuji A Harada R Harada A 《Nature》2007,448(7151):366-369
A number of proteins are known to be involved in apical/basolateral transport of proteins in polarized epithelial cells. The small GTP-binding protein Rab8 was thought to regulate basolateral transport in polarized kidney epithelial cells through the AP1B-complex-mediated pathway. However, the role of Rab8 (Rab8A) in cell polarity in vivo remains unknown. Here we show that Rab8 is responsible for the localization of apical proteins in intestinal epithelial cells. We found that apical peptidases and transporters localized to lysosomes in the small intestine of Rab8-deficient mice. Their mislocalization and degradation in lysosomes led to a marked reduction in the absorption rate of nutrients in the small intestine, and ultimately to death. Ultrastructurally, a shortening of apical microvilli, an increased number of enlarged lysosomes, and microvillus inclusions in the enterocytes were also observed. One microvillus inclusion disease patient who shows an identical phenotype to Rab8-deficient mice expresses a reduced amount of RAB8 (RAB8A; NM_005370). Our results demonstrate that Rab8 is necessary for the proper localization of apical proteins and the absorption and digestion of various nutrients in the small intestine. 相似文献
7.
Materials showing simultaneous ferroelectric and magnetic ordering are attracting a great deal of interest because of their unusual physics and potential applications. Hemberger et al. have reported relaxor-like dielectric properties and colossal magnetocapacitance (in excess of 500%) for the cubic spinel compound CdCr2S4 and related isomorphs, concluding that CdCr2S4 is a multiferroic relaxor. We argue here, however, that their results might also be explained by a conductive artefact. 相似文献
8.
Low beta diversity of herbivorous insects in tropical forests 总被引:1,自引:0,他引:1
Novotny V Miller SE Hulcr J Drew RA Basset Y Janda M Setliff GP Darrow K Stewart AJ Auga J Isua B Molem K Manumbor M Tamtiai E Mogia M Weiblen GD 《Nature》2007,448(7154):692-695
Recent advances in understanding insect communities in tropical forests have contributed little to our knowledge of large-scale patterns of insect diversity, because incomplete taxonomic knowledge of many tropical species hinders the mapping of their distribution records. This impedes an understanding of global biodiversity patterns and explains why tropical insects are under-represented in conservation biology. Our study of approximately 500 species from three herbivorous guilds feeding on foliage (caterpillars, Lepidoptera), wood (ambrosia beetles, Coleoptera) and fruit (fruitflies, Diptera) found a low rate of change in species composition (beta diversity) across 75,000 square kilometres of contiguous lowland rainforest in Papua New Guinea, as most species were widely distributed. For caterpillars feeding on large plant genera, most species fed on multiple host species, so that even locally restricted plant species did not support endemic herbivores. Large plant genera represented a continuously distributed resource easily colonized by moths and butterflies over hundreds of kilometres. Low beta diversity was also documented in groups with differing host specificity (fruitflies and ambrosia beetles), suggesting that dispersal limitation does not have a substantial role in shaping the distribution of insect species in New Guinea lowland rainforests. Similar patterns of low beta diversity can be expected in other tropical lowland rainforests, as they are typically situated in the extensive low basins of major tropical rivers similar to the Sepik-Ramu region of New Guinea studied here. 相似文献
9.
10.
Koebel CM Vermi W Swann JB Zerafa N Rodig SJ Old LJ Smyth MJ Schreiber RD 《Nature》2007,450(7171):903-907
The capacity of immunity to control and shape cancer, that is, cancer immunoediting, is the result of three processes that function either independently or in sequence: elimination (cancer immunosurveillance, in which immunity functions as an extrinsic tumour suppressor in naive hosts); equilibrium (expansion of transformed cells is held in check by immunity); and escape (tumour cell variants with dampened immunogenicity or the capacity to attenuate immune responses grow into clinically apparent cancers). Extensive experimental support now exists for the elimination and escape processes because immunodeficient mice develop more carcinogen-induced and spontaneous cancers than wild-type mice, and tumour cells from immunodeficient mice are more immunogenic than those from immunocompetent mice. In contrast, the equilibrium process was inferred largely from clinical observations, including reports of transplantation of undetected (occult) cancer from organ donor into immunosuppressed recipients. Herein we use a mouse model of primary chemical carcinogenesis and demonstrate that equilibrium occurs, is mechanistically distinguishable from elimination and escape, and that neoplastic cells in equilibrium are transformed but proliferate poorly in vivo. We also show that tumour cells in equilibrium are unedited but become edited when they spontaneously escape immune control and grow into clinically apparent tumours. These results reveal that, in addition to destroying tumour cells and sculpting tumour immunogenicity, the immune system of a naive mouse can also restrain cancer growth for extended time periods. 相似文献