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低碳锰钢中周期性带状组织 总被引:6,自引:0,他引:6
用扫描电镜和电子探针研究了低碳锰钢中的周期性带状组织,结果表明,在全部研究用钢中,钢锭经热轧后均出现这种组织,其严重程度随钢的成分而异,并随坯带加工顺序而增加,带状组织与锰的显微偏析等因素有关,适当的调整碳锰以及形成模跨铁素体带的转变产物可降低带状组织的严重程度。 相似文献
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Characterization of a regulatory unit that controls melanization and affects longevity of mosquitoes
Melanization is an innate immune response in arthropods that encapsulates and kills invading pathogens. One of its rate-limiting
steps is the activation of prophenoloxidase (PPO), which is controlled by an extracellular proteinase cascade and serpin inhibitors.
The molecular composition of this system is largely unknown in mosquitoes with the exception of serpin-2 (SRPN2), which was
previously identified as a key negative regulator of melanization. Using reverse genetic and biochemical techniques, we identified
the Anopheles gambiae clip-serine proteinase CLIPB9 as a PPO-activating proteinase, which is inhibited by SRPN2. Double knockdown of SRPN2 and
CLIPB9 reversed the pleiotrophic phenotype induced by SRPN2 silencing. This study identifies the first inhibitory serpin-serine
proteinase pair in mosquitoes and defines a regulatory unit of melanization. Additionally, the interaction of CLIPB9 and SRPN2
affects the life span of adult female mosquitoes and therefore constitutes a well-defined potential molecular target for novel
late-life acting insecticides. 相似文献
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