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排序方式: 共有88条查询结果,搜索用时 46 毫秒
1.
电荷转移多金属氧酸盐的研究进展 总被引:3,自引:0,他引:3
概述了多金属氧酸盐与TTF类π电子有机给体形成的电荷转移盐研究的简短历史和新近进展,着重评述了它们的合成、结构、性质以及研究方法. 相似文献
2.
一类拟线性第二边值问题的存在唯一性 总被引:1,自引:0,他引:1
本文在f(t,x),fx(t,x),β(t)连续,fx(t,x)≥-β(t),β(t)≤π20+α24,β(t)π20+α24,π0为方程αsinx2+xcosx2=0的最小正根条件下,证明了第二边值问题.x"=αx+f(t,x),x(0)=a,x(1)=b对于任给实数α,a,b都有唯一解 相似文献
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Elia J Glessner JT Wang K Takahashi N Shtir CJ Hadley D Sleiman PM Zhang H Kim CE Robison R Lyon GJ Flory JH Bradfield JP Imielinski M Hou C Frackelton EC Chiavacci RM Sakurai T Rabin C Middleton FA Thomas KA Garris M Mentch F Freitag CM Steinhausen HC Todorov AA Reif A Rothenberger A Franke B Mick EO Roeyers H Buitelaar J Lesch KP Banaschewski T Ebstein RP Mulas F Oades RD Sergeant J Sonuga-Barke E Renner TJ Romanos M Romanos J Warnke A Walitza S Meyer J Pálmason H Seitz C Loo SK Smalley SL 《Nature genetics》2012,44(1):78-84
Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric disorder of unknown etiology. We performed a whole-genome copy number variation (CNV) study on 1,013 cases with ADHD and 4,105 healthy children of European ancestry using 550,000 SNPs. We evaluated statistically significant findings in multiple independent cohorts, with a total of 2,493 cases with ADHD and 9,222 controls of European ancestry, using matched platforms. CNVs affecting metabotropic glutamate receptor genes were enriched across all cohorts (P = 2.1 × 10(-9)). We saw GRM5 (encoding glutamate receptor, metabotropic 5) deletions in ten cases and one control (P = 1.36 × 10(-6)). We saw GRM7 deletions in six cases, and we saw GRM8 deletions in eight cases and no controls. GRM1 was duplicated in eight cases. We experimentally validated the observed variants using quantitative RT-PCR. A gene network analysis showed that genes interacting with the genes in the GRM family are enriched for CNVs in ~10% of the cases (P = 4.38 × 10(-10)) after correction for occurrence in the controls. We identified rare recurrent CNVs affecting glutamatergic neurotransmission genes that were overrepresented in multiple ADHD cohorts. 相似文献
5.
B. C. Yoo S-H. Hong J-L. Ku Y-H. Kim Y-K. Shin S-G. Jang I-J. Kim S-Y. Jeong J-G. Park 《Cellular and molecular life sciences : CMLS》2009,66(2):350-364
Comparative analysis of proteomes using 5-fluorouracil (5-FU)-resistant human colon cancer cell line revealed that decreased
galectin-3 expression was significantly associated with retarded proliferation. However, in the presence of 5-FU proliferation
rate of cells with suppressed galectin-3 expression did not differ from that of cells with normal galectin-3 expression, even
galectin-3 suppression augmented apoptosis. Mechanism by which galectin-3 regulates cancer cell proliferation has been identified
in immunoprecipitates of the anti-galectin-3 antibody. Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) was identified
as a protein interacting with galectin-3. Interestingly, while galectin-3 protein was not affected by the hnRNP Q level, its
suppression was accompanied by a decrease in hnRNP Q expression. The present study demonstrates that galectin-3 stabilizes
hnRNP Q via complex formation, and reduction in the hnRNP Q level leads to slow proliferation and less susceptibility to 5-FU.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
B.C.Yoo; S-H.Hong; These two authors contributed equally to this work.
Received 10 September 2008; received after revision 19 October 2008; accepted 07 November 2008 相似文献
6.
库少平 《西安交通大学学报》2006,40(12):1454-1457
对普通三角函数进行了推广,给出了椭圆三角函数的定义,指出椭圆三角函数是周期函数,存在最大值和最小值,并在定义域内连续可导.对椭圆正弦函数进行了一系列仿真研究,结果表明,椭圆正弦函数可作为波形发生器的发生函数,可产生方波、普通正弦波、脉冲波、处于普通正弦波和方波之间的波形、处于普通正弦波和脉冲波之间的各种波形,且函数形式是一致的,波形的幅值、频率、初始相位都易于调整.这种波形发生函数能方便地进行数学处理与分析,波形发生原理能应用于各类相关波形发生场合. 相似文献
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高校教学督导中加强对学生学习督导的探索 总被引:3,自引:0,他引:3
高校教育督导包括督教、督管、督学三个方面。针对目前高校教学督导工作中较少注意督学现状。从“督导学生”的角度出发,介绍了包括学生座谈、问卷调查、教学咨询、听课观察等直接和间接的督学实践过程;分析学生学习的实际情况;探讨督导工作中督学的作用、实践操作性、效果检测,以及如何用正确的观点、科学的态度来分析判断与评价学生的学习,做到督之有力,监之有方,导贯其中。 相似文献
9.
E. Marchut M. Gumińska T. Kędryna Cz. Radzikowski H. Kuśnierczyk 《Cellular and molecular life sciences : CMLS》1988,44(1):25-27
Summary Mouse transplanted tumors, in contrast to normal tissues, contain a pyruvate kinase (PK) variant sensitive to the inhibitory action of L-cysteine and less sensitive to saturated fatty acids than the normal enzyme. In selected normal and tumor materials two fractions of PK were separated. Fraction A (20–30% (NH4)2SO4 saturation) dominated in normal liver, and fraction B (50–60% (NH4)2SO4 saturation) in skeletal muscles and Ehrlich ascites tumor. Only this fraction B from tumor material was sensitive to L-cysteine, and seems to contain a tumor-specific PK variant which might be considered as a marker of neoplastic transformation in a broad spectrum of mouse experimental tumors. 相似文献
10.
利用坐标变换法给出了一类扩散过程转移密度的显式上下界估计,推广了Zheng W.和Qian Z.的有关结果. 相似文献