Maxwell's role in turning the concept of model into the methodology of modeling

This is a contribution towards a history and philosophy of modeling in its early stages in electromagnetism. In 1873, James Clerk Maxwell (1831–1879) hinted at the methodology of modeling at the end of his Treatise on Electricity and Magnetism. We focus on Maxwell's impact on physicists who immediately followed him, specifically Oliver Lodge (1851–1940) and George Francis FitzGerald (1851–1901). We begin with the role that the scientific concept of model played in the late nineteenth century, as assessed by Ludwig Boltzmann (1844–1906). We then discuss the role of hypothesis as a methodology, the appeal to (dynamical) illustration, and the way Maxwell applied model and working model in his studies of electromagnetism. We show that for Maxwell these key terms were kept distinct, but Lodge did not maintain these distinctions and, in this regard, FitzGerald followed Lodge. Notwithstanding Lodge's influence, Fitzgerald modified Maxwell's theory based on the mechanical model he designed, thereby implicitly taking the first step towards modeling. This methodology consists in drawing consequences from the (mechanical) model to the (electrodynamic) theory and modifying the latter in light of the functioning of the former. At the core of our argument is the thesis that it was a methodological novelty to move from the concept of model to the methodology of modeling. The introduction of modeling as a new methodology into physics in the late nineteenth century was a major event which deserves proper recognition.     

谈“十四五”生态保护与绿色发展的生态关系

 从“十四五”保护与发展的生态关系角度，探讨了生态保护与绿色发展的十大生态关系，阐述了生态保护和绿色发展中的一系列有关生态关系的生态智慧及生态技术，并对长江、黄河等流域的生态保护和修复提出了相关建议。     

体育消费的学理脉络、统计内容及其实施策略

采用文献资料法，依次从学理脉络、统计内容及其实施策略展开关于体育消费以及体育消费统计的讨论。认为：从学理上看，体育消费作为一个复杂概念，既牵涉宏观经济社会发展，也与文化意识形态紧密联系；而作为准确把握体育市场、把脉体育发展情况的基础性工作之一，体育消费统计则应该避免将体育消费概念泛化。应以体育政策为导向，面向人民的美好生活需要，对接国民经济统计制度，考虑建构以“体育教育与培训、体育文化与娱乐、体育保健与康复、体育传媒与信息、体育衣着耐用品、其他体育用品与服务、个人间接体育消费”为核心指标的统计框架，并通过长效工作方案的设计使体育消费统计工作制度化，通过统计调查制度的建构使体育消费统计执行有效化，通过统计数据的测算推算使体育消费统计结果精准化。     

The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the “triple membrane bypass” pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier.