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Hohenegger M. Sonntag A. Szemeredi I. 《Cellular and molecular life sciences : CMLS》1975,31(7):812-814
Cellular and Molecular Life Sciences - Bilateral resection of the whole superficial kidney cortex (approximately 75% of glomeruli) was carried out in rats. These animals needed some 2 days longer... 相似文献
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Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose 总被引:7,自引:0,他引:7
Guse AH da Silva CP Berg I Skapenko AL Weber K Heyer P Hohenegger M Ashamu GA Schulze-Koops H Potter BV Mayr GW 《Nature》1999,398(6722):70-73
Cyclic ADP-ribose (cADPR) is a natural compound that mobilizes calcium ions in several eukaryotic cells. Although it can lead to the release of calcium ions in T lymphocytes, it has not been firmly established as a second messenger in these cells. Here, using high-performance liquid chromatography analysis, we show that stimulation of the T-cell receptor/CD3 (TCR/CD3) complex results in activation of a soluble ADP-ribosyl cyclase and a sustained increase in intracellular levels of cADPR. There is a causal relation between increased cADPR concentrations, sustained calcium signalling and activation of T cells, as shown by inhibition of TCR/CD3-stimulated calcium signalling, cell proliferation and expression of the early- and late-activation markers CD25 and HLA-DR by using cADPR antagonists. The molecular target for cADPR, the type-3 ryanodine receptor/calcium channel, is expressed in T cells. Increased cADPR significantly and specifically stimulates the apparent association of [3H]ryanodine with the type-3 ryanodine receptor, indicating a direct modulatory effect of cADPR on channel opening. Thus we show the presence, causal relation and biological significance of the major constituents of the cADPR/calcium-signalling pathway in human T cells. 相似文献
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Bilateral resection of the whole superficial kidney cortex (approximately 75% of glomeruli) was carried out in rats. These animals needed some 2 days longer to restore their sodium balance when placed from low to high sodium intake in comparison with rats subjected to other types of partial nephrectomy. 相似文献
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