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Heras SR Thomas MC García-Canadas M de Felipe P García-Pérez JL Ryan MD López MC 《Cellular and molecular life sciences : CMLS》2006,63(12):1449-1460
A comparative analysis of 40 Trypanosoma cruzi L1Tc elements showed that the 2A self-cleaving sequence described in viruses is present in them. Of these elements, 72% maintain
the canonical 2A motif (DxExNPGP). A high percentage has a conserved point mutation within the motif that has not been previously
described. In vitro and in vivo expression of reporter polyproteins showed that the L1Tc2A sequence is functional. Mutations within certain L1Tc2A sequences
affect the efficiency of the cleavage. The data indicate that the L1Tc2A sequence may be influencing the L1Tc enzymatic machinery
determining the composition and level of the translated products. The residues located immediately upstream of the 2A consensus
sequence increase the cleaving efficiency and appear to stabilize the relative amount of translated products.
These authors contributed equally to this work.
Received 26 January 2006; received after revision 11 April 2006; accepted 21 April 2006 相似文献
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碲锡铅(Pb1-xSnxTe)是一种禁带宽度可调的三元化合物半导体,用它不仅可制备814μm的高灵敏度的红外探测器,而且可以制备长波红外可调谐激光器. 相似文献
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