Active out-of-sequence thrust faulting in the central Nepalese Himalaya

Recent convergence between India and Eurasia is commonly assumed to be accommodated mainly along a single fault--the Main Himalayan Thrust (MHT)--which reaches the surface in the Siwalik Hills of southern Nepal. Although this model is consistent with geodetic, geomorphic and microseismic data, an alternative model incorporating slip on more northerly surface faults has been proposed to be consistent with these data as well. Here we present in situ cosmogenic 10Be data indicating a fourfold increase in millennial timescale erosion rates occurring over a distance of less than 2 km in central Nepal, delineating for the first time an active thrust fault nearly 100 km north of the surface expression of the MHT. These data challenge the view that rock uplift gradients in central Nepal reflect only passive transport over a ramp in the MHT. Instead, when combined with previously reported 40Ar-39Ar data, our results indicate persistent exhumation above deep-seated, surface-breaking structures at the foot of the high Himalaya. These results suggest that strong dynamic interactions between climate, erosion and tectonics have maintained a locus of active deformation well to the north of the Himalayan deformation front.     

FHA-RING ubiquitin ligases in cell division cycle control

Despite the common occurrence of forkhead associated (FHA) phosphopeptide-binding domains and really interesting new gene (RING) E3 ubiquitin ligase domains, gene products containing both an N-terminal FHA domain and C-terminal RING domain constitute a highly distinctive intersection. Characterized FHA-RING ligases include the two vertebrate proteins, Checkpoint with FHA and RING (Chfr) and RING finger 8 (Rnf8), as well as three fungal proteins, Defective in mitosis (Dma1), Chf1 and Chf2. These FHA-RING ligases play roles in negative regulation of the cell division cycle, apparently by coupling protein phosphorylation events to specific ubiquitylation of target proteins. Here, the available data on upstream and downstream regulation of and by FHA-RING ligases are reviewed. Received 24 April 2008; received after revision 18 June 2008; accepted 20 June 2008