排序方式: 共有8条查询结果,搜索用时 15 毫秒
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Halina Szpilmanowa Jolanta Stachurska 《Cellular and molecular life sciences : CMLS》1968,24(8):784-785
Résumé Nous avons constaté que l'activité spécifique du facteur de Hageman dans le fluide synovial de malades atteints de polyarthrite chronique évolutive est beaucoup plus elevée que celle d'autres agents de coagulation. L'activité du facteur de Hageman a été isolée du fluide synovial et de la suspension de leucocytes par adsorption sur kaolin et élution au pH alcalin. 相似文献
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Parkhill J Sebaihia M Preston A Murphy LD Thomson N Harris DE Holden MT Churcher CM Bentley SD Mungall KL Cerdeño-Tárraga AM Temple L James K Harris B Quail MA Achtman M Atkin R Baker S Basham D Bason N Cherevach I Chillingworth T Collins M Cronin A Davis P Doggett J Feltwell T Goble A Hamlin N Hauser H Holroyd S Jagels K Leather S Moule S Norberczak H O'Neil S Ormond D Price C Rabbinowitsch E Rutter S Sanders M Saunders D Seeger K Sharp S Simmonds M Skelton J Squares R Squares S Stevens K 《Nature genetics》2003,35(1):32-40
Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are closely related Gram-negative beta-proteobacteria that colonize the respiratory tracts of mammals. B. pertussis is a strict human pathogen of recent evolutionary origin and is the primary etiologic agent of whooping cough. B. parapertussis can also cause whooping cough, and B. bronchiseptica causes chronic respiratory infections in a wide range of animals. We sequenced the genomes of B. bronchiseptica RB50 (5,338,400 bp; 5,007 predicted genes), B. parapertussis 12822 (4,773,551 bp; 4,404 genes) and B. pertussis Tohama I (4,086,186 bp; 3,816 genes). Our analysis indicates that B. parapertussis and B. pertussis are independent derivatives of B. bronchiseptica-like ancestors. During the evolution of these two host-restricted species there was large-scale gene loss and inactivation; host adaptation seems to be a consequence of loss, not gain, of function, and differences in virulence may be related to loss of regulatory or control functions. 相似文献
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Loftus B Anderson I Davies R Alsmark UC Samuelson J Amedeo P Roncaglia P Berriman M Hirt RP Mann BJ Nozaki T Suh B Pop M Duchene M Ackers J Tannich E Leippe M Hofer M Bruchhaus I Willhoeft U Bhattacharya A Chillingworth T Churcher C Hance Z Harris B Harris D Jagels K Moule S Mungall K Ormond D Squares R Whitehead S Quail MA Rabbinowitsch E Norbertczak H Price C Wang Z Guillén N Gilchrist C Stroup SE Bhattacharya S Lohia A Foster PG Sicheritz-Ponten T Weber C Singh U Mukherjee C El-Sayed NM 《Nature》2005,433(7028):865-868
Entamoeba histolytica is an intestinal parasite and the causative agent of amoebiasis, which is a significant source of morbidity and mortality in developing countries. Here we present the genome of E. histolytica, which reveals a variety of metabolic adaptations shared with two other amitochondrial protist pathogens: Giardia lamblia and Trichomonas vaginalis. These adaptations include reduction or elimination of most mitochondrial metabolic pathways and the use of oxidative stress enzymes generally associated with anaerobic prokaryotes. Phylogenomic analysis identifies evidence for lateral gene transfer of bacterial genes into the E. histolytica genome, the effects of which centre on expanding aspects of E. histolytica's metabolic repertoire. The presence of these genes and the potential for novel metabolic pathways in E. histolytica may allow for the development of new chemotherapeutic agents. The genome encodes a large number of novel receptor kinases and contains expansions of a variety of gene families, including those associated with virulence. Additional genome features include an abundance of tandemly repeated transfer-RNA-containing arrays, which may have a structural function in the genome. Analysis of the genome provides new insights into the workings and genome evolution of a major human pathogen. 相似文献
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Halina Szpilman J. Prokopowicz S. Niewiarowski 《Cellular and molecular life sciences : CMLS》1969,25(1):77-78
Résumé Les extraits granulocytaires racourcissent le temps de coagulation de plasmas déficients en facteurs VIII, IX et XII. Une activité paracoagulante particulièrement élevée se manifeste dans les subfractions de granulocytes contenant des lysosomes et d'autres structures cytoplasmatiques. 相似文献
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Résumé On a obtenu 2 pools majeurs de-carotène dans l'homogénat du mycélium deB. trispora. L'un d'eux est associé à la fraction sédimentable à 4,900×g, l'autre aux globules de matière grasse, dans le cytoplasme. 相似文献
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Wetzel C Hu J Riethmacher D Benckendorff A Harder L Eilers A Moshourab R Kozlenkov A Labuz D Caspani O Erdmann B Machelska H Heppenstall PA Lewin GR 《Nature》2007,445(7124):206-209
Touch and mechanical pain are first detected at our largest sensory surface, the skin. The cell bodies of sensory neurons that detect such stimuli are located in the dorsal root ganglia, and subtypes of these neurons are specialized to detect specific modalities of mechanical stimuli. Molecules have been identified that are necessary for mechanosensation in invertebrates but so far not in mammals. In Caenorhabditis elegans, mec-2 is one of several genes identified in a screen for touch insensitivity and encodes an integral membrane protein with a stomatin homology domain. Here we show that about 35% of skin mechanoreceptors do not respond to mechanical stimuli in mice with a mutation in stomatin-like protein 3 (SLP3, also called Stoml3), a mammalian mec-2 homologue that is expressed in sensory neurons. In addition, mechanosensitive ion channels found in many sensory neurons do not function without SLP3. Tactile-driven behaviours are also impaired in SLP3 mutant mice, including touch-evoked pain caused by neuropathic injury. SLP3 is therefore indispensable for the function of a subset of cutaneous mechanoreceptors, and our data support the idea that this protein is an essential subunit of a mammalian mechanotransducer. 相似文献
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Peacock CS Seeger K Harris D Murphy L Ruiz JC Quail MA Peters N Adlem E Tivey A Aslett M Kerhornou A Ivens A Fraser A Rajandream MA Carver T Norbertczak H Chillingworth T Hance Z Jagels K Moule S Ormond D Rutter S Squares R Whitehead S Rabbinowitsch E Arrowsmith C White B Thurston S Bringaud F Baldauf SL Faulconbridge A Jeffares D Depledge DP Oyola SO Hilley JD Brito LO Tosi LR Barrell B Cruz AK Mottram JC Smith DF Berriman M 《Nature genetics》2007,39(7):839-847
Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only approximately 200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA-mediated interference pathway, telomere-associated transposable elements and spliced leader-associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host-pathogen interactions and parasite survival in the macrophage. 相似文献
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Cz. Maśliński S. M. Maśliński Halina Weinrauder 《Cellular and molecular life sciences : CMLS》1963,19(5):258-259
Résumé Les animaux adaptés à l'histamine sont moins sensible à l'histamine et aux produits d'une réaction antigène-anticorps. La tolérance des cobayes adaptés est augmentée particulièrement après une exposition supplémentaire dans l'aérosol histaminique. 相似文献
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