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Joshi S Guleria RS Pan J Bayless KJ Davis GE Dipette D Singh US 《Cellular and molecular life sciences : CMLS》2006,63(23):2859-2870
Developmental exposure to ethanol impairs fetal brain development and causes fetal alcohol syndrome. Although the cerebellum
is one of the most alcohol-sensitive brain areas, signaling mechanisms underlying the deleterious effects of ethanol on developing
cerebellar granule neurons (CGNs) are largely unknown. Here we describe the effects of in vivo ethanol exposure on neurite formation in CGNs and on the activation of Rho GTPases (RhoA and Rac1), regulators of neurite
formation. Exposure of 7-day-old rat pups to ethanol for 3 h moderately increased blood alcohol concentration (BAC) (∼40 mM)
and inhibited neurite formation and Rac1 activation in CGNs. Longer exposure to ethanol for 5 h resulted in higher BAC (∼80 mM),
induced apoptosis, inhibited Rac1, and activated RhoA. Studies demonstrated a regulatory role of Rho GTPases in differentiation
of cerebellar neurons, and indicated that ethanol-associated impairment of Rho GTPase signaling might contribute to brain
defects observed in fetal alcohol syndrome.
Received 16 July 2006; received after revision 12 September 2006; accepted 13 October 2006 相似文献
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将基于独立成分分析(independent component analysis,ICA)技术的盲分解方法(blind signal separation,BSS)应用于遥感混合像元的定量分解,解决了幅度不确定性问题,实现了从高光谱数据中同时得到定量的组分光谱信息和组分权重信息。通过数值模拟实验提出了光谱反演区间的选择方法,进一步完善了该算法,且讨论了算法的稳健性。以陕西省横山县为试验区,从HYPERION高光谱影像中反演了各像元的植被覆盖度,并利用SPOT5影像进行了精度验证,结果表明该方法具有较高的精度。 相似文献
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Immediate circulatory response to high altitude hypoxia in man 总被引:3,自引:0,他引:3
S B Roy J S Guleria P K Khanna J R Talwar S C Manchanda J N Pande V S Kaushik P S Subba J E Wood 《Nature》1968,217(5134):1177-1178
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