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Erwin Knecht Carmen Aguado Jaime Cárcel Inmaculada Esteban Juan Miguel Esteve Ghita Ghislat José Félix Moruno José Manuel Vidal Rosana Sáez 《Cellular and molecular life sciences : CMLS》2009,66(15):2427-2443
In higher organisms, dietary proteins are broken down into amino acids within the digestive tract but outside the cells, which
incorporate the resulting amino acids into their metabolism. However, under certain conditions, an organism loses more nitrogen
than is assimilated in the diet. This additional loss was found in the past century to come from intracellular proteins and
started an intensive research that produced an enormous expansion of the field and a dispersed literature. Therefore, our
purpose is to provide an updated summary of the current knowledge on the proteolytic machinery involved in intracellular protein
degradation and its physiological and pathological relevance, especially addressed to newcomers in the field who may find
further details in more specialized reviews. However, even providing a general overview, this is an extremely wide field and,
therefore, we mainly focus on mammalian cells, while other cells will be mentioned only for comparison purposes. 相似文献
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