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Neuroactive steroids: State of the art and new perspectives 总被引:1,自引:0,他引:1
Melcangi RC Garcia-Segura LM Mensah-Nyagan AG 《Cellular and molecular life sciences : CMLS》2008,65(5):777-797
Neuroactive steroids include synthetic steroidal compounds and endogenous steroids, produced by endocrine glands (hormonal
steroids) or the nervous tissue (neurosteroids), which regulate neural functions. These steroids bind to nuclear receptors
or act through the activation of membrane-associated signaling pathways to modulate various important processes including
the development of the nervous system, neural plasticity and the adaptive responses of neurons and glial cells under pathological
conditions. Reviewed and updated in the present paper are the pleiotropic and protective abilities of neuroactive steroids.
The fundamental evidence and knowledge gained constitute a profound background that offers interesting possibilities for developing
effective strategies against several disorders of the nervous system.
Received 3 September 2007; received after revision 24 October 2007; accepted 29 October 2007 相似文献
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Roglio I Bianchi R Giatti S Cavaletti G Caruso D Scurati S Crippa D Garcia-Segura LM Camozzi F Lauria G Melcangi RC 《Cellular and molecular life sciences : CMLS》2007,64(9):1158-1168
In this study we have assessed the effect of testosterone (T), dihydrotestosterone (DHT) and 5αandrostan-3α, 17β-diol (3α-diol)
therapies on diabetic neuropathy. Diabetes was induced in adult male rats by the injection of streptozotocin and resulted
in decreased T and increased 3α-diol levels in plasma and in decreased levels of pregnenolone and DHT in the sciatic nerve.
Moreover, a reduced expression of the enzyme converting Tinto DHT (i.e., the 5α-reductase) also occurs at the level of sciatic nerve, suggesting that the decrease of DHT levels could be due to
an impairment of this enzyme. Chronic treatment for 1 month with DHT or 3α-diol increased tail nerve conduction velocity and
partially counteracted the increase of thermal threshold induced by diabetes. Treatment with DHT increased tibial Na+,K+-ATPase activity and the expression of myelin protein P0 in the sciatic nerve.DHT, 3α-diol and T reversed the reduction of
intra-epidermal nerve fiber density induced by diabetes. These observations indicate that T metabolites can reverse behavioral,
neurophysiological, morphological and biochemical alterations induced by peripheral diabetic neuropathy.
I. Roglio, R. Bianchi: These authors contributed equally to this study.
Received 4 January 2007; received after revision 13 February 2007; accepted 27 March 2007 相似文献
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