More on the need for circadian,circaseptan and circannual optimization of cyclosporine therapy

Summary Cyclosporine chronotherapy of pancreas-allotransplanted rats revealed, beyond a circadian stage-dependence of equal daily doses, further gain in graft function from doses varying from day to day with an about 7-day periodicity, the first highest dose being given on the 3rd or 5th day after surgery.     

Timing of single daily meal influences relations among human circadian rhythms in urinary cyclic AMP and hemic glucagon,insulin and iron

Summary Relations among circadian rhythms in serum iron, glucagon and insulin and urinary cyclic AMP excretion differ drastically when diurnally active, nocturnally resting human adults consume all daily food for one week as breakfast only and for another week as dinner only—a finding of interest to diverse fields, e.g., for optimizing certain kinds of therapy or for a better utilization of calories.Supported by grants (No. RR-400 from the General Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health, USPHS and Nos. 5-K6-GM-13, 981 and 1RO1-CA-14445-01) and grant No. 20, Fondation de l'industrie pharmaceutique pour la recherche.     

Weitere Untersuchungen zur Induktion von Keimblattveränderungen durch Röntgenstrahlen

Summary A previous experiment withEranthis showed thatRoentgen irradiation of undivided embryos led to a change in the number of cotyledons. In the present publication, the induction of anomalies of the cotyledon was shown after irradiation of early embryo stages on the mother plant in Arabidopsis thaliana, an example of a plant with complete embryos.Which aberration type (synkotyl, anisokotyl, trikotyl, tetrakotyl or multiple seedlings) will arise, seems to be determined neither by theRoentgen dose nor by the stage of development on irradiation. The appearance of predominately regular trikotyl types after application of 2000r, and their gradual disappearance with increasing doses in favour of the irregular trikotyl types, suggests that in the lower doses the main influences are upon the purely chemical reactions in the embryos, which are overlaid by cell damages occurring in a directly biophysical way with increase of the physical primary acts and lead to irregular growth.

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Die Arbeit wurde mit Unterstützung der Deutschen Forschungsgemeinschaft durchgeführt.     

Persisting circadian rhythm in hepatic glycogen of mice during inanition and dehydration

Zusammenfassung Eine Circadianrhythmik des Mäuseleberglycogens lässt sich durch Standardisierung anderer biologischer Frequenzen und «Lärm» isolieren. Dies gelingt auch nach Entzug von Futter oder Futter und Wasser. Persistente Rhythmen mit grosser Amplitude kennzeichnen eine Reihe physiologischer Funktionen nach Futter- und Flüssigkeitsentzug und können als Chossatphänomene bezeichnet werden.

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Work supported by the Elsa U. Pardee Foundation, the National Aeronautics and Space Administration of the USA (NsG-517) and the US Public Health Service (5-K6-GM-13).     

具有Markov延迟的网络化控制系统控制与通信协同设计

由于网络化控制系统分析与设计的复杂性,其控制与通信协同设计问题一直没有得到解决。该文讨论了一类离散线性时不变网络化控制系统在服从介质访问约束和传感器一控制器端存在Markov随机延迟的情况下控制与通信协同设计问题,提出了系统均方稳定的条件。采用静态通信序列,使通信序列和控制器可以分别设计,应用V-K迭代算法设计最优周期控制增益。仿真算例验证了系统在所设计的最优控制器下达到均方稳定。     

More on the need for circadian, circaseptan and circannual optimization of cyclosporine therapy

Cyclosporine chronotherapy of pancreas-allotransplanted rats revealed, beyond a circadian stage-dependence of equal daily doses, further gain in graft function from doses varying from day to day with an about 7-day periodicity, the first highest dose being given on the 3rd or 5th day after surgery.     

Circadian variation in urinary melatonin in clinically healthy women in Japan and the United States of America

Summary Urinary melatonin excretion is lower in East-Asian (Japanese) than in North-American (whites of mixed ethnic origin) women. Moreover, a statistically significant circadian rhythm is demonstrated by population-mean cosinor in the data pool from both groups of women. Furthermore, statistical significance characterizes interactions of effects from geographic differences (between ethnic groups) with temporal factors. Such spatio-temporal interactions await further scrutiny with a view inter alia of carcinogenesis as it is influenced by a spectrum of intermodulating rhythms.Supported by U.S. Public Health Service (5-K6-GM-13981-17), National Cancer Institute (1R01-CA-14445-05 and N01-CP-5-5702), National Institute of Occupational Safety and Health (OH-00631-01), National Institute of Aging (AG-00158), Environmental Protection Agency (R804513-01-0), Swedish Medical Research Council grant 3371 and the St Paul Ramsey Medical Research and Education Foundation. R.B. Sothern and Jung-Keun Lee, Scientists, Chronobiology Laboratories, University of Minnesota provided valuable help.