避孕压力为啥由女性承担

<正>也不是没人研究过男性避孕药,只是面对这"野火烧不尽,春风吹又生"的精子们,科学家们绞尽脑汁却依旧所获不多。避孕,是男女两个人的事,但在选择避孕方式上,女性安装宫内节育器的比例要比男性做输精管结扎术的比例大得多,市面上的避孕药品也几乎都偏向于女性。像宫内节育器这样的避孕措施对女性的伤害还真不小。最可怕的是有很多女性即使带上宫内节育器还会有怀孕的情况,而这样的情况往往会导致宫外孕。     

‘Action substances’ of peripheral nerve re-visited

Fifty years ago, four action substances were described as being liberated from peripheral nerve in the course of activity. An attempt has been made to update this information. Confirmatory evidence is available that acetylcholine and thiamine do play a role in the course of activity. However, the question of the relationship in time between their release and the electrical events, and the possible effect on specific ionic gating mechanisms, remains unclarified. The liberation of potassium has been found to be a transmembrane K efflux, and the question of the existence of another substance similar to thiamine has not been pursued.a member of the Editorial Board of EXPERIENTIA from 1974 to 1982     

The effect of dehydration on the neurohypophyseal blood flow in rats with hereditary diabetes insipidus

Summary Neurohypophyseal blood flow increases in water-deprived rats. This increase is independent of vasopressin release, since it occurs even in rats with hereditary defect of hypothalamic vasopressin synthesis.Acknowledgment. The technical assistance of D. Vilimovská is acknowledged.     

生态遗传算法在模糊系统辨识中的应用

给出一类模糊系统的模糊神经网络模型 .提出一种实用的生态算子 ,构建的生态遗传新算法有效解决了基本遗传算法的“早熟”问题 .采用新算法实现模糊神经网络模型的辨识 ,提高了辨识精度 .实例仿真结果验证了新算法在模糊系统辨识中的有效性     

带有油膜轴承的裂纹轴转子系统故障特征分析

通过大量仿真计算，对于带有油膜轴承的裂纹轴转子系统的故障特征进行了较为全面的论证．这些特征是通过三维频谱、转速-振幅特性和周期分岔特性来表达的．除了分析裂纹轴转子系统的基本故障特征外，还重点分析了作为故障特征的一个重要方面的非线性行为．为诊断转子系统裂纹故障提供了理论依据．     

描述石灰石分解的分数维收缩核模型及模拟

基于分形理论中颗粒表面积与颗粒当量半径以及表面积与体积之间的关系式，考虑固体颗粒表面形貌的不规则性，建立了化学反应起控制作用的固体颗粒分解的分数维收缩核模型，并将其用来模拟石灰石颗粒的缎烧分解过程，取得了较为满意的模拟结果．同时，将其模拟结果与收缩核模型的模拟结果进行了比较．     

Degradation of the mitochondrial complex I assembly factor TMEM126B under chronic hypoxia

Cell stress such as hypoxia elicits adaptive responses, also on the level of mitochondria, and in part is mediated by the hypoxia-inducible factor (HIF) 1α. Adaptation of mitochondria towards acute hypoxic conditions is reasonably well understood, while regulatory mechanisms, especially of respiratory chain assembly factors, under chronic hypoxia remains elusive. One of these assembly factors is transmembrane protein 126B (TMEM126B). This protein is part of the mitochondrial complex I assembly machinery. We identified changes in complex I abundance under chronic hypoxia, in association with impaired substrate-specific mitochondrial respiration. Complexome profiling of isolated mitochondria of the human leukemia monocytic cell line THP-1 revealed HIF-1α-dependent deficits in complex I assembly and mitochondrial complex I assembly complex (MCIA) abundance. Of all mitochondrial MCIA members, we proved a selective HIF-1-dependent decrease of TMEM126B under chronic hypoxia. Mechanistically, HIF-1α induces the E3-ubiquitin ligase F-box/WD repeat-containing protein 1A (β-TrCP1), which in turn facilitates the proteolytic degradation of TMEM126B. Attenuating a functional complex I assembly appears critical for cellular adaptation towards chronic hypoxia and is linked to destruction of the mitochondrial assembly factor TMEM126B.     

如何吃才健康

正在肥胖的人体血管中,经常有动脉粥样硬化形成的结块到处弥散。这些病人当初怎么了,怎么就来这了,为什么会出现这样的症状?其实,最大的原因经常也是最为简单的:病从口入我们人类的自然史,所有辉煌与暗淡,成功与困难,都经常取决于食物的丰盛或匮乏。这种情形直到20世     

Der Einfluss von Röntgenstrahlen und Hypothermie auf den Hämoglobingehalt des einzelnen Erythrozyten neugeborener Hausmäuse

Summary New-born mice were exposed to a dosage of 600 R X-rays. If the mice were irradiated under extreme hypothermy, we found a decrease of the content of hemoglobin in the single erythrocyte below the level of animals that were subjected to irradiation or hypothermy only.