Effects of morphine administration on cerebellar guanosine 3′,5′-monophosphate

Summary An increase in mouse cerebellar C-GMP levels, during acute morphine treatment was observed, which was possibly related to the decrease in C-GMP phosphodiesterase levels also observed in acute treatment. Chronic treatment lowered C-GMP levels as did abrupt withdrawal without naloxone.     

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

We have recently shown that loss of heterozygosity of specific markers, including those at 10q23, 17p13-p15 and 16q24, can occur in the stromal and epithelial compartments of primary invasive breast carcinomas. Here, we demonstrate high frequencies of somatic mutations in TP53 (encoding tumor protein p53) and PTEN (encoding phosphate and tensin homolog) in breast neoplastic epithelium and stroma. Mutations in TP53 and PTEN are mutually exclusive in either compartment. In contrast, mutations in WFDC1 (16q24, encoding WAP four-disulfide core domain 1) occur with low frequency in the stroma.     

Effects of morphine administration on cerebellar guanosine 3',5'-monophosphate.

An increase in mouse cerebellar C-GMP levels during acute morphine treatment was observed, which was possibly related to the decrease in C-GMP phosphodiesterase levels also observed in acute treatment. Chronic treatment lowered C-GMP levels as did abrupt withdrawal without naloxone.     

‘One common matter’ in Descartes' physics: the Cartesian concepts of matter quantities,weight and gravity

ABSTRACT

It is common to assume that Descartes did not have a conception of an object's matter density independently of its size, but this is a rather incomplete assessment of the early modern natural philosopher's theory. Key to our understanding of Descartes's physics is a consideration of the ratios between the quantities of the different types of matter in which an object consists. As these ratios determine the degree of an object's porosity and elasticity, they also affect in Descartes's theory the phenomena of gravity and weight.