Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes

Summary A dissociation between inhibition of RNA synthesis and cell lysis was observed when thymocytes of adrenalectomized rats were incubated with high concentrations of pregn-4-ene-11-ol-3, 20-dione and pregna-1,4-diene-11-ol-3,20-dione. In contrast, no dissociation of these effects was found with the typical glucocorticoids cortisol and corticosterone, nor with their 1,4-diene analogs under the same conditions.Acknowledgments. This work was supported by grants from the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina to the Instituto de Biologia y Medicina Experimental and the Programa de Regulación Hormonal y Metabólica as well as by financial help from the Secretaría de Ciencia y Tecnología.     

一类连续小波的构造及其性质

小波分析是国际上新兴的一个前沿研究课题,已成为众多学科共同关注的热点.小波函数的构造问题是小波理论分析与应用研究的基础.文章提出了一类连续性小波函数的构造方法,同时证明了其满足允许条件,并利用该方法构造出了几个小波函数,同时利用MATLAB程序绘出了相应的小波函数及其Fourier变换(频谱)图.     

Sperm viability in the reproductive tract of females in a population of Sceloporus mucronatus exhibiting asynchronous reproduction

Asynchronous reproduction is a common phenomenon in high-elevation populations of lizards from Central México. Sperm storage in the reproductive tract of females is the mechanism for making oocyte fertilization possible. Our study addresses questions related to functional oviductal sperm storage of females mating on different dates throughout the reproductive season. A population of Sceloporus mucronatus with copulation in the summer and ovulation in the fall was chosen for this experiment. Eleven females that copulated in the field during June and 13 females that copulated in captivity during August were maintained in the laboratory until parturition. The number of pregnant females and the litter sizes produced in each experimental group were indicative of the viability of the stored sperm. Sperm stored in the reproductive tract of females were able to fertilize eggs after 4 months. No significant differences were found in the number of pregnant females between the 2 experimental groups nor in the litter sizes that they produced. We found that the amount of time sperm were held in the female reproductive tract (ca. 3 months) had no effect on the capacity of sperm to fertilize eggs. Histological examination of 8 oviducts collected before the mating season eliminated the possibility of sperm storage from one year to the next. In this system, sperm retention could have evolved as a response mechanism to deal with the asynchrony between sexes in the reproductive cycles. However, we cannot rule out alternative hypotheses.     

中小企业技术创新的现状与对策

分析了中国中小企业技术创新的特点和现状,指出中小企业技术创新能力不高、缺乏技术创新的人才队伍、产学研合作机制不健全、融资渠道少等问题,提出重视中小企业技术创新人才的培养、优化金融环境、建立健全产学研合作机制、通过培育中介组织推动企业自主创新、选择适合企业实际情况的技术创新战略等措施.     

人体经络复杂网络路由问题的求解

为了研究经络—免疫—神经—内分泌网络(jingluo-immune-nerve-endocrinenetwork)学说,采用复杂网络定义、模型、算法和理论,对穴位在经络中的信息传递方式、交互条件、路由途径、高导电性进行了测试和验证,建立了经络的复杂网络路由模型,证实了该网络的存在·信息物质沿经络路线传播,经络循行也有确定的方向和速度,确立了经络的基本功能是传递及调控生命信息物质为经络研究开辟了一条新的方法·     

互联网中的标准结构熵的时间演化分析

通过对Internet标准结构熵随时间变化规律的分析发现,Internet的标准结构熵具有随时间而逐渐降低的趋势,以riesling节点获得的Internet监测数据的计算结果为例,Internet标准结构熵从2000年4月的最大值0.379下降至2004年5月的0.318,月平均下降幅度为0.12%,即由高熵值拓扑结构向低熵值拓扑结构的状态变化.由此可知Internet的宏观拓扑结构在演化过程中存在着拓扑结构的信息代谢.     

基于VC和VIP的面向对象知识表示

知识表示是人工智能研究的基本问题之一。通过在 Visual C+ +的类中引入Visual Prolog的推理机制提出了一种基于 VC和 VIP的面向对象知识表示方法 ,完善了 Visual C+ +对象的推理功能 ,进一步增强了面向对象的知识表示能力以及 VisualProlog的接口和计算能力 ,并通过实验验证了方法的性能     

基于示例学习的模糊控制器原理

简要回顾了示例学习的基本知识 ,并在此基础上 ,针对基本模糊控制器依赖人为经验的局限性 ,提出了一种基于示例学习的模糊控制器并给出了其设计原理。这种设计方法明显提高了控制器的自学习能力 ,从而能够进一步改善控制器的性能     

SPE-HPLC测定风湿马钱片中的马钱子碱

采用固相萃取进行样品前处理,建立固相萃取-高效液相色谱法(SPE-HPLC)测定风湿马钱片中马钱子碱含量的分析方法。采用PXC阳离子交换固相萃取小柱净化,C18(250 mm×4.6 mm,5μm)色谱柱,流动相为乙腈-0.01 mol/L庚烷磺酸钠与0.02 mol/L磷酸二氢钾等量混合溶液(用体积分数为10%的磷酸调节p H值为2.8),二者体积比为21∶79,流速为1.0 m L/min,检测波长为262 nm,柱温为30℃。结果发现,马钱子碱在40~60μg/m L范围线性关系良好,相关系数为0.9993,平均回收率为99.6%~101.0%,RSD值为1.04%。该方法操作简便、准确,重现性好,适用于风湿马钱片中马钱子碱的含量测定。