排序方式: 共有4条查询结果,搜索用时 265 毫秒
1
1.
J.A. Wilson C.M. Bosio M.K. Hart 《Cellular and molecular life sciences : CMLS》2001,58(12-13):1826-1841
Ebola viruses belong to the family Filoviridae, which are among the most virulent infectious agents known. These viruses cause acute, and frequently fatal, hemorrhagic fever in humans and nonhuman primates. Currently, no vaccines or treatments are available for human use. This review describes Ebola viruses, with a particular focus on the status of research efforts to develop vaccines and therapeutics and to identify the immune mechanisms of protection. 相似文献
2.
夏海峰 《淮阴师范学院学报(自然科学版)》2002,1(4):14-16
本文指出仪洪勋和Brosch G在具有三个判别的CM公共值的亚纯函数的唯一性定理中,关于对数函数的导数是整函数的推导,可以用指数函数求导的方法来证明.改进了仪洪勋和Brosch G关于重值与唯一性定理. 相似文献
3.
White MD Bosio CM Duplantis BN Nano FE 《Cellular and molecular life sciences : CMLS》2011,68(18):3019-3031
Many of the live human and animal vaccines that are currently in use are attenuated by virtue of their temperature-sensitive
(TS) replication. These vaccines are able to function because they can take advantage of sites in mammalian bodies that are
cooler than the core temperature, where TS vaccines fail to replicate. In this article, we discuss the distribution of temperature
in the human body, and relate how the temperature differential can be exploited for designing and using TS vaccines. We also
examine how one of the coolest organs of the body, the skin, contains antigen-processing cells that can be targeted to provoke
the desired immune response from a TS vaccine. We describe traditional approaches to making TS vaccines, and highlight new
information and technologies that are being used to create a new generation of engineered TS vaccines. We pay particular attention
to the recently described technology of substituting essential genes from Arctic bacteria for their homologues in mammalian
pathogens as a way of creating TS vaccines. 相似文献
4.
Pain relief by xenograft of subarachnoid microencapsulated bovine chromaffin cells in cancer patients 总被引:5,自引:0,他引:5
XUE Yilong HE Limin LI Liushu WANG Jie WANGZhenfu LI Xinjian ZHANG Li CM Xin ZHU Jianhu LUOYun ZHONG Daguang LI Yanling 《自然科学进展(英文版)》2000,10(12):919-924
The bovine chromaffin cells (BCC) implanted into the subarachnoid space can release analgesic
substances such as opioid peptides and ealeeholamines. Clinical trials have provided the evidence that the implantation of polyvinylchloride ( PVC) hollow fiber encapsulated BCC by surgery can relief the pain in cancer patients. In the present study, BCC were encapsulated in alginate-polylysine-alginate (APA) mieroencapsules which protect the grafting of xenogeneic cells from host immune system anil allow BCC to function effectively without using immunosuppression agents. The microencapsulated BCCs (5 X 106~—8 X 106) were transplanted into the subarachnoid space I^._s of 17 patients who suffered from chronic cancer pain and had to have long-term administration of analgesics. The pain scores and morphine intake tesl showed that microencapsulated BCC graft totally stopped the chronic pain in three of the patients over a period of 200 days and in the other three over a period of 100 days. The resulls suggesl thai APA microencapsulated BCC xenotransplantation could be a novel alternative approach to managing pain of cancer patients. 相似文献
1