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Cellular and Molecular Life Sciences -     

Activité gonadotrope d'un extrait d'urines de femmes en ménopause

Summary An extract from pooled postmenopausal urine has been investigated for its gonadotrophic activity. Dose-response curves have been constructed for its total gonadotrophic activity (stimulation of estrogen secretion as reflected by the uterine weight increase in immature mice) and for its ICSH activity (stimulation of androgen secretion as reflected by the ventral prostate weight increase in hypophysectomised immature rats). In hypophysectomised immature rats, the extract produced repair of the interstitial cells of the testes and complete spermatogenesis. It contains, therefore, FSH as well as ICSH activity in comparable amounts, a fact which opens up interesting therapeutic possibilities.     

Activité gonadotrope d'un extrait d'urines de femmes en ménopause

Summary In agreement with earlier observations on hypophysectomized male rats, a purified extract from pooled menopausal urine has been shown to contain follicle-stimulating (FSH) as well as luteinizing (LH) activity. Its administration to immature hypophysectomized female rats increased ovarian and uterine weights and induced follicle growth and the formation of corpora lutea. If the activity of the extract is measured in standardized units by bioassay in intact female mice using the uterine weight, the dose needed for corpus luteum formation in the hypophysectomized female rat seems to be approximately ten times higher than the dose producing interstitial cell repair and complete spermatogenesis in the hypophysectomized male.

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2^e Communication: Effets sur les ovaires de rates impubères hypophysectomisées.     

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A bio-implantable solid-state camera for long-term video-recording of abdominal organs in situ

Summary A new solid-state camera was constructed and implanted in sheep. It permits continuous or selective videorecording of the ovary in the unrestrained animal during an entire oestrous cycle (16 days).Supported by research grants from the Ford Foundation (700-0615A) and the Medical Research Council of Canada (MT-5692).