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Antibacterial peptide from H. pylori 总被引:6,自引:0,他引:6
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Inducible antibacterial defence system in Drosophila 总被引:19,自引:0,他引:19
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Organisms co-habiting with bacteria have developed efficient bactericidal agents to control their microbe-rich environment. The Ascaris nematode lives in its final development stages in the gut of its host and is believed to feed on bacteria. Ascaris suum survive in pig intestine while A. lumbricoides is the principal species in humans. Here we show that A. suum and A. lumbricoides both produce linear (cecropin P1) and cysteine-rich (ASABF) peptides with activity against either gram-negative or gram-positive bacteria, respectively. Thus nematodes rely in part on a peptide-based antibacterial system for digestion of bacteria, which may also confer protection against infection. Cecropin P1 was previously isolated from pig intestine but we can now conclude that was due to contaminating nematodes. 相似文献
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The problem of fault-tolerant controller design for a class of polytopic uncertain systems with actuator faults is studied in this paper. The actuator faults are presented as a more general and practical continuous fault model. Based on the affine quadratic stability (AQS), the stability of the polytopic uncertain system is replaced by the stability at all corners of the polytope. For a wide range of problems including H∞ and mixed H 2 /H∞ controller design, sufficient conditions are derived to guarantee the robust stability and performance of the closed-loop system in both normal and fault cases. In the framework of the linear matrix inequality (LMI) method, an iterative algorithm is developed to reduce conservativeness of the design procedure. The effectiveness of the proposed design is shown through a flight control example. 相似文献
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Yuxing Mao Ching Y.Suen Wei He .State Key Laboratory of Power Transmission Equipment & System Security New Technology Chongqing University Chongqing P.R.China .Centre for Pattern Recognition Machine Intelligence Concordia University Montreal QC HG M Canada 《系统工程与电子技术(英文版)》2011,(6):1003-1009
A new approach to extraction of affine invariant features of contour image and matching strategy is proposed for shape recognition.Firstly,the centroid distance and azimuth angle of each boundary point are computed.Then,with a prior-defined angle interval,all the points in the neighbor region of the sample point are considered to calculate the average distance for eliminating noise.After that,the centroid distance ratios(CDRs) of any two opposite contour points to the barycenter are achieved as the representation of the shape,which will be invariant to affine transformation.Since the angles of contour points will change non-linearly among affine related images,the CDRs should be resampled and combined sequentially to build one-by-one matching pairs of the corresponding points.The core issue is how to determine the angle positions for sampling,which can be regarded as an optimization problem of path planning.An ant colony optimization(ACO)-based path planning model with some constraints is presented to address this problem.Finally,the Euclidean distance is adopted to evaluate the similarity of shape features in different images.The experimental results demonstrate the efficiency of the proposed method in shape recognition with translation,scaling,rotation and distortion. 相似文献
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Two distinct steps in nuclear envelope assembly can be assayed in vitro: the protein-mediated binding of nuclear-specific vesicles to chromatin, and the subsequent fusion of these vesicles to enclose the chromatin within a double nuclear membrane. Nuclear vesicle fusion, like fusion in the secretory pathway, requires ATP and cytosol and is inhibited by nonhydrolysable GTP analogues. The sensitivity of nuclear vesicle fusion to GTP-gamma S requires a GTP-dependent soluble factor, the properties of which are strikingly similar to a GTP-dependent Golgi binding factor (GGBF) that inhibits Golgi vesicle fusion in the presence of GTP-gamma S and belongs to the ADP-ribosylation factor (ARF) family of small GTPases. In the presence of GTP-gamma S, ARF proteins and alpha-, beta-, gamma-, delta-COP ('coatomer') subunits are associated with Golgi transport vesicles, but the exact roles of ARF proteins in secretion are not yet understood. We report here that purified ARF1 and GGBF have GTP-dependent soluble factor activity in the nuclear vesicle fusion assay. Our results show that the function of ARF is not limited to the Golgi apparatus, and indicate that there may be a link between the formation of nuclear vesicles during mitosis and proteins involved in secretion. 相似文献
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