Spin label studies of ATP phosphoribosyltransferase of E. coli.

Covalently bound bromoacetamide nitroxides have been used to detect the conformational changes and enzyme association induced by its feedback inhibitor, histidine.     

Fibrin stabilizing factor (F XIII) and collagen polymerization

Summary Factor XIII induces a decrease and a modification in the collagen polymerization, probably due to the formation of transamidation bonds. This property has some importance in wound healing.     

幂权Beurling代数上的次线性算子

建立了Ｂｅｕｒｌｉｎｇ代数的分解特征．这个特征被用来对一大类次线性算子建立它们在幂权Ｂｅｕｒｌｉｎｇ代数上的有界性质，而对于无权情形此结论却不成立．     

Fenofibrate inhibits angiogenesis in vitro and in vivo

Fenofibrate, a peroxisome proliferator-activated receptor (PPAR)-alpha activator, used as a normolipidemic agent, is thought to offer additional beneficial effects in atherosclerosis. Since angiogenesis is involved in plaque progression, hemorrhage, and instability, the main causes of ischemic events, this study was designed to evaluate the action of fenofibrate on angiogenesis. Our results show that fenofibrate (i) inhibits endothelial cell proliferation induced by angiogenic factors, followed at high concentrations by an increase in apoptosis, (ii) inhibits endothelial cell migration in a healing wound model, (iii) inhibits capillary tube formation in vitro, and (iv) inhibits angiogenesis in vivo. Concerning the mechanism of action, the inhibition of endothelial cell migration by fenofibrate can be explained by a disorganization of the actin cytoskeleton. At the molecular level, fenofibrate markedly decreased basic fibroblast growth factor-induced Akt activation and cyclooxygenase 2 gene expression. This inhibition of angiogenesis could participate in the beneficial effect of fenofibrate in atherosclerosis.     

一类有关圆盘乘子算子的加权不等式

对一类有关圆盘乘子的算子，建立了幂权加权不等式，作为上述结果的一个应用，给出了Ｓｔｅｉｎ－Ｗｅｉｓｓ的一结果的简单证明。     

Mn2+ electron spin resonance studies on ATP phosphoribosyltransferase fromE. coli

Summary ESR binding studies of Mn²⁺ with each of the substrates and products suggests that substrate bridge complexes are formed in the reaction. This prediction is confirmed, comparing Mn²⁺+ADP and Mn²⁺+ADP+enzyme spectra.We thank V. M. Fernández for helpful discussions.