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Glucagon-like peptide-1(1-37) inhibits chemokine-induced migration of human CD4-positive lymphocytes
Nikolaus Marx Mathias Burgmaier Philipp Heinz Mirjam Ostertag Angelina Hausauer Helga Bach Renate Durst Vinzenz Hombach Daniel Walcher 《Cellular and molecular life sciences : CMLS》2010,67(20):3549-3555
The present study examined the effect of GLP-1(1-37) on chemokine-induced CD4-positive lymphocyte migration as an early and
critical step in atherogenesis. Pretreatment with GLP-1(1-37) reduced the SDF-induced migration of isolated human CD4-positive
lymphocytes in a concentration-dependent manner. Similar effects were seen when RANTES was used as a chemokine. GLP-1(1-37)’s
effect on CD4-positive lymphocyte migration was mediated through an early inhibition of chemokine-induced PI-3 kinase activity.
Downstream, GLP-1(1-37) inhibited SDF-induced phosphorylation of MLC and cofilin and limited f-actin formation as well as
ICAM3 translocation. Furthermore, exendin-4 inhibited SDF-induced migration of CD4-positive lymphocytes similarly to GLP-1(1-37),
and transfection of these cells with GLP-1 receptor siRNA abolished GLP-1(1-37)’s action on chemokine-induced ICAM3 translocation,
suggesting an effect mediated via the GLP-1 receptor. Thus, GLP-1(1-37) inhibits chemokine-induced CD4-positive lymphocyte
migration by inhibition of the PI3-kinase pathway and via the GLP-1 receptor. This effect provides a potential novel mechanism
for how GLP-1(1-37) may modulate vascular disease. 相似文献
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J. M. Dellacha Angelina V. Fontanive 《Cellular and molecular life sciences : CMLS》1965,21(6):351-352
Zusammenfassung Eine Methode für die quantitative Bestimmung N-endstándiger Aminosäuren, Proteine und Peptide mittels Dünnschichtchromatographie wurde entwickelt.
This work was supported in part by Grant No. 5 RO5 TW 00071-02 from the United States Public Health Service, USA. 相似文献
This work was supported in part by Grant No. 5 RO5 TW 00071-02 from the United States Public Health Service, USA. 相似文献
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