Hemmung des Thiouracilkropfes der Ratte durch synthetischen Vitamin-A-Methyläther

Summary The hyperplasia and hyperaemia of the thyreoidea of rats caused by thiouracil treatment can be largely avoided by simultaneous doses of vitamin-A methylether.     

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

Epigenetic silencing in cancer cells is mediated by at least two distinct histone modifications, polycomb-based histone H3 lysine 27 trimethylation (H3K27triM) and H3K9 dimethylation. The relationship between DNA hypermethylation and these histone modifications is not completely understood. Using chromatin immunoprecipitation microarrays (ChIP-chip) in prostate cancer cells compared to normal prostate, we found that up to 5% of promoters (16% CpG islands and 84% non-CpG islands) were enriched with H3K27triM. These genes were silenced specifically in prostate cancer, and those CpG islands affected showed low levels of DNA methylation. Downregulation of the EZH2 histone methyltransferase restored expression of the H3K27triM target genes alone or in synergy with histone deacetylase inhibition, without affecting promoter DNA methylation, and with no effect on the expression of genes silenced by DNA hypermethylation. These data establish EZH2-mediated H3K27triM as a mechanism of tumor-suppressor gene silencing in cancer that is potentially independent of promoter DNA methylation.     

Management Factors Influencing Location Selection Decisions of Independent Filmmakers: An Exploratory Case Study

This is an exploratory case study of a management issue that confronts filmmakers: how do they select locations for their films? The outcome of those decisions can have vast and immediate effects upon the profitability of a film. This is a sometimes shadowy, but significant industry with a major economic impact. For systems theory advocates, students, and explorers, this study demonstrates that investigative, immersive action research techniques can be used to explore what are otherwise hidden, somewhat cloistered business organizations and industry structures that are ordinarily closed to outsiders. The soft-system of this industry that is rooted upon trust, loyalty, alliances, relationships, and other non-financial bonds influence its decisions, and its institutional performance. While this research is focused upon a fragment of the overall film industry worldwide, and is thus limited in the universality of the propositions that subsequently emerge, this study can serve as a springboard for research into other soft systems, from which new knowledge of managerial perspectives can emerge.     

Über eine Tetrahydroisochinolinverbindung mit analgetischer Wirkung

Summary Ro 4-1778/1 (1-(p-Chlorphenethyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline) showed in pharmacological tests distinct analgetic effects similar to those of codeine as well as some spasmolytic activity resembling that of papaverine, whereas its side effects were absent or at least considerably less pronounced than those known for codeine.     

Dünnschicht-Chromatographie auf Linienglas

Summary A modification of the thin layer chromatography on grooved chromatoplate is described, which reduces the usual equipment to a very simple and inexpensive extent.     

Experimenteller Beitrag zur Frage von Nierenschäden bei Abusus von phenazetinhaltigen Schmerzmitteln

Summary In view of the chronic interstitial nephritis observed in man after years of abuse of phenacetin-containing analgesics, rats were subjected to oral loading-tests with Saridon and its active components. It was not possible, however, to induce interstitial nephritis experimentally. Trials with Saridon will be continued on rats having undergone additional renal loading-tests and in which renal damage has been previously induced.