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排序方式: 共有147条查询结果,搜索用时 15 毫秒
1.
综合近十几年国内外有关内电解法废水处理技术研究文献 ,综述了内电解在理论、实践应用方面的研究现状 .对内电解的反应机理、铁屑改性、助剂和催化剂的选用、内电解处理设备的研制等方面进行了研究 ,并对内电解法在目前研究中存在的问题及今后的研究方向做了进一步探讨 相似文献
2.
Kris Meerschaert Moe Phyu Tun Eline Remue Ariane De Ganck Ciska Boucherie Berlinda Vanloo Gisèle Degeest Joël Vandekerckhove Pascale Zimmermann Nitin Bhardwaj Hui Lu Wonhwa Cho Jan Gettemans 《Cellular and molecular life sciences : CMLS》2009,66(24):3951-3966
Zonula occludens proteins (ZO) are postsynaptic density protein-95 discs large-zonula occludens (PDZ) domain-containing proteins that play a fundamental role in the assembly of tight junctions and establishment of cell polarity. Here, we show that the second PDZ domain of ZO-1 and ZO-2 binds phosphoinositides (PtdInsP) and we identified critical residues involved in the interaction. Furthermore, peptide and PtdInsP binding of ZO PDZ2 domains are mutually exclusive. Although lipid binding does not seem to be required for plasma membrane localisation of ZO-1, phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P 2) binding to the PDZ2 domain of ZO-2 regulates ZO-2 recruitment to nuclear speckles. Knockdown of ZO-2 expression disrupts speckle morphology, indicating that ZO-2 might play an active role in formation and stabilisation of these subnuclear structures. This study shows for the first time that ZO isoforms bind PtdInsPs and offers an alternative regulatory mechanism for the formation and stabilisation of protein complexes in the nucleus. 相似文献
3.
4.
Arboleda VA Lee H Parnaik R Fleming A Banerjee A Ferraz-de-Souza B Délot EC Rodriguez-Fernandez IA Braslavsky D Bergadá I Dell'Angelica EC Nelson SF Martinez-Agosto JA Achermann JC Vilain E 《Nature genetics》2012,44(7):788-792
IMAGe syndrome (intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita and genital anomalies) is an undergrowth developmental disorder with life-threatening consequences. An identity-by-descent analysis in a family with IMAGe syndrome identified a 17.2-Mb locus on chromosome 11p15 that segregated in the affected family members. Targeted exon array capture of the disease locus, followed by high-throughput genomic sequencing and validation by dideoxy sequencing, identified missense mutations in the imprinted gene CDKN1C (also known as P57KIP2) in two familial and four unrelated patients. A familial analysis showed an imprinted mode of inheritance in which only maternal transmission of the mutation resulted in IMAGe syndrome. CDKN1C inhibits cell-cycle progression, and we found that targeted expression of IMAGe-associated CDKN1C mutations in Drosophila caused severe eye growth defects compared to wild-type CDKN1C, suggesting a gain-of-function mechanism. All IMAGe-associated mutations clustered in the PCNA-binding domain of CDKN1C and resulted in loss of PCNA binding, distinguishing them from the mutations of CDKN1C that cause Beckwith-Wiedemann syndrome, an overgrowth syndrome. 相似文献
5.
We use the sociological systems theory proposed by Niklas Luhmann to complement a socially-oriented view of knowledge with the role of technical infrastructure in knowledge creation. We highlight the self-referential character of knowledge creation and draw upon illustrative examples from open-source software. We discuss why knowledge creation processes are often prone to breakdown and propose three conditions that may stabilize knowledge creation processes: perceptibility, systemic memory, and modularity. 相似文献
6.
从四株猴头菌在培养期间对木质素、半纤维素,纤维素的降解和有关酶活变化的规律进行研究。结果表明: 木质素降解量大于半纤维素降解量,半纤维素降解量大于纤维素降解量。不同菌株木质素分解活性不同,木质素分解活性强的菌株,半纤维素和纤维素的降解也较多,羧甲基纤维素酶活性和滤纸酶活性大体一致。胞外多酚氧化酶活性以培养最初期为高,后期活性很低,但子实体中的多酚氧化酶活性很高,以原基期为最高。这表明子实体中的多酚氧酶是在子实体中产生的,而不是在菌丝体中产生而后输送到子实体中去的。 相似文献
7.
沉淀二氧化硅载银抗菌剂的制备及其抗菌性能 总被引:13,自引:0,他引:13
以沉淀二氧化硅为载体,吸附硝酸银后,在500℃下灼烧,制备了具有抗菌功能的线银沉淀二氧化硅抗菌剂,并检验了其抗菌性能;还对抗菌剂的抗菌机理进行了初步探讨。测试结果表明,沉淀二氧化硅的载银量在7%以上时,所制备的抗菌剂对绿脓杆菌、大肠杆菌和枯草杆菌的杀菌率达到100%,具有优异的抗菌性能,可用于抗菌塑料、抗菌食品包装、抗菌卫生纸和抗菌纺织制品等领域。 相似文献
8.
代谢工程和作物改良 总被引:2,自引:0,他引:2
郑康乐 《杭州师范学院学报(自然科学版)》2002,(4)
基因组学和植物生理生化是通过基因工程改良作物的基础 .借助于这些基础研究 ,通过基因工程调控代谢途径 ,提高了油菜籽粒中的油脂含量和拟南芥种子中的维生素 E活性 ,使水稻的胚乳中能合成维生素A原 ,增加了水稻在碱性土壤中吸收铁的能力 ,展示了代谢工程在定向改良作物中的应用前景 相似文献
9.
A Delbarre B P Roques J B le Pecq 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1977,284(1):81-84
Many symmetrical bis [9-methoxy 2-ellipticinium] dioxodiazaalkanes salts were synthesized from 9-methoxy ellipticine. An analog derivative of 9-hydroxy ellipticine was also prepared. Some of these dimers bind to DNA by a bifunctionnal mode of intercalation. 相似文献
10.
Rosy Eloy Dominique Vuitton J. -P. Vaultier Michèle Klein J. F. Grenier 《Cellular and molecular life sciences : CMLS》1976,32(5):647-649
Summary Pretreatment of donor lymphoid cells with cortisone has been shown to depress the T-cell subpopulation responsible for cellular proliferation in the GVH reaction. A quantitative assay as well as the histological criteria of the GVH reaction have been used in this study to demonstrate the presence of cortisone-sensitive T-cells within the Peyer's patches as well as in the spleen and mesenteric lymph nodes in the rat.This work was supported by a grant of the Délégation Générale à la Recherche Scientifique et Technique (No. 74-7-0619). 相似文献