Über die Wirkung von 7,12-Dimethylbenz(a)-anthrazen auf die Synthese der Lactatdehydrogenase-Isoenzyme in menschlichen Fibroblasten

Summary The effect of 7,12-Dimethylbenz(a)anthracene (DMBA) on the activity of lactate dehydrogenase (LDH)-isoenzymes was studied in human fibroblast cultures. 3 isoenzyme components were separated by discelectrophoresis. A clear reduction in the enzymeactivity of the first and third component was observed, while the other fraction was little or not affected. The incorporation of radioactive amino acids in proteins of the LDH-isoenzyme bands shows the same trend.