全文获取类型
收费全文 | 274篇 |
免费 | 6篇 |
国内免费 | 5篇 |
专业分类
系统科学 | 4篇 |
丛书文集 | 1篇 |
理论与方法论 | 13篇 |
现状及发展 | 175篇 |
研究方法 | 10篇 |
综合类 | 72篇 |
自然研究 | 10篇 |
出版年
2019年 | 2篇 |
2018年 | 14篇 |
2017年 | 7篇 |
2016年 | 6篇 |
2015年 | 8篇 |
2013年 | 6篇 |
2012年 | 11篇 |
2011年 | 8篇 |
2010年 | 5篇 |
2009年 | 3篇 |
2008年 | 10篇 |
2007年 | 2篇 |
2006年 | 7篇 |
2005年 | 8篇 |
2004年 | 3篇 |
2003年 | 2篇 |
2002年 | 4篇 |
2001年 | 4篇 |
1999年 | 3篇 |
1998年 | 2篇 |
1997年 | 3篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1991年 | 3篇 |
1990年 | 4篇 |
1989年 | 3篇 |
1988年 | 4篇 |
1987年 | 3篇 |
1986年 | 7篇 |
1985年 | 5篇 |
1984年 | 5篇 |
1983年 | 2篇 |
1982年 | 5篇 |
1981年 | 6篇 |
1980年 | 7篇 |
1979年 | 5篇 |
1978年 | 9篇 |
1977年 | 6篇 |
1976年 | 9篇 |
1975年 | 4篇 |
1974年 | 5篇 |
1973年 | 11篇 |
1972年 | 6篇 |
1971年 | 7篇 |
1970年 | 8篇 |
1968年 | 10篇 |
1967年 | 2篇 |
1966年 | 4篇 |
1964年 | 6篇 |
1961年 | 2篇 |
排序方式: 共有285条查询结果,搜索用时 31 毫秒
1.
IntroductionThemultimodelapproachappearsasapowerfultechniquetodealwithcomplex,nonlinearand/orilldefinedsystemsrepresentedusingasetofsimplelinearorsmoothlynonlinearmodelseachofthemallowingthegenerationofapartialcontroller.Differentapproachesexistintheliterature[1,2]tocopewiththetwokeypointsofthemultimodel/multicontrolstrategy:themodelbasisdeterminationandtheuseofpartialcontrollersinordertoderiveaglobalone.Hence,itappearsobviousthatoneofthemainobjectstofocusoninthemultimodel/multicontrolapproach… 相似文献
2.
V. Pli<ska 《Cellular and molecular life sciences : CMLS》1991,47(3):216-221
Summary Binding studies in various biological systems frequently indicate the presence of several binding sites for a biologically active ligand. They differ in their affinity for the ligand in question, binding capacity, and Hill coefficient, which suggests differences in the mechanisms of the binding site-ligand interactions. Identification of the true receptors (sites initiating a cellular response) appears to be difficult. Three clusters of binding sites for oxytocin were found on rat myometrial cells. The oxytocin receptor seems to be linked to the medium-affinity site; the cooperation between the high-and medium-affinity sites in eliciting the uterotonic response seems likely, but lacks experimental proof. Dose-response analysis in partially irreversibly inhibited uterus preparations, the method of equipotent doses (Furchgott-Bursztyn method), and structure-activity analysis of oxytocin-like peptides acting as competitive inhibitors of oxytocin, turned out to be suitable for pharmacological analysis of this receptor system. 相似文献
3.
Summary Hexoprenaline potentiated the14C-aminopyrine uptake (a reliable index of H+ generation) of isolated rat gastric cells stimulated by 10–6–10–4 mol/l carbachol, and inhibited that in response to 10–4 mol/l histamine without and in the presence of propranolol. It is concluded that hexoprenaline acts as a partial agonist on parietal cell H2-receptors and that -adrenoceptor activation may functionally modualte gastric acid secretion.Acknowledgments. S. Maliski, Institute of Rheumatology, Warszawa, held a fellowship of the Alexander v. Humboldt-Foundation. The study was supported by the Deutsche Forschungsgemeinschaft. The skilful technical assistance of Mrs R. Maier and Mr R. Beer is gratefully acknowledged. 相似文献
4.
5.
B. Jazdowska-Zagrodzińska B. Matuszewski 《Cellular and molecular life sciences : CMLS》1978,34(6):777-778
Summary Lamellar structures in oogonial and spermatogonial cells of gall midges were found to form a complicated system of intranuclear compartments inside which all heteropycnotic chromosomes present in the germ-line cells of these insects are located. In this way, the heteropycnotic S-chromosomes are separated by the nuclear lamellae from the remaining, decondensed chromosomes (E-chromosomes) of the interphase germ-line nucleus.This investigation was supported in part under Contract DPKBN/52/76-II.1.3.10. with the Polish Academy of Sciences. 相似文献
6.
Summary Natural cell-mediated cytotoxicity of normal murine Peyer's patch cells against Ehrlich ascites carcinoma was found in a short-term51Cr release assay. Peyer's patch and lymph node cells showed natural cytotoxicity at approximately the same level.Acknowledgments. This work was supported by grant No. 10.5 from the Polish Academy of Sciences. 相似文献
7.
J. Kędziora M. Soszyński G. Bartosz H. Witas W. Leyko 《Cellular and molecular life sciences : CMLS》1980,36(8):926-927
Summary A statistically significant decrease of prealbumin and statistically significant increases of alpha2-macroglobulin and IgA were found in blood plasma of patients with Down's syndrome using quantitative crossed immunoelectrophoresis.We are indebted to Prof. T.C. Bøg-Hansen, University of Copenhagen, for the helpful discussion of our results. 相似文献
8.
J. Lamprecht R. Figurski Z. Lewicki A. Pawłowski 《Cellular and molecular life sciences : CMLS》1979,35(10):1386-1387
Summary Complete removal of villous as well as upper-crypt epithelium was achieved in vivo by vibration of an intestinal segment using tetraphenylboron sodium (TPB) as a disassociation agent.Acknowledgments. The authors thank Hicol Industrieterrein De Bosschen for supplying TPB. Research was supported by MR-II 1.3.14.p.2 grant. 相似文献
9.
A. B. Ślebodziński 《Cellular and molecular life sciences : CMLS》1979,35(4):549-550
Summary The effect of ethanol on thyroxine (T4) accumulation in the hypothalamus (H), pituitary gland (P) and cerebrospinal fluid (CSF) has been investigated in 1–15-day-old rabbits. It has been found that H or CSF serum ratios decreased with age by about 2 in the course of 13 postnatal days. Stable T4 resulted in an increase of125I-T4 in H, P and CSF. Ethanol per se caused an increase in transfer and accumulation of radiothyroxine or made the changes after loading animals with carrier T4 more pronounced. 相似文献
10.
Zohra Dhouafli Karina Cuanalo-Contreras El Akrem Hayouni Charles E. Mays Claudio Soto Ines Moreno-Gonzalez 《Cellular and molecular life sciences : CMLS》2018,75(19):3521-3538
Protein misfolding and aggregation into fibrillar deposits is a common feature of a large group of degenerative diseases affecting the central nervous system or peripheral organs, termed protein misfolding disorders (PMDs). Despite their established toxic nature, clinical trials aiming to reduce misfolded aggregates have been unsuccessful in treating or curing PMDs. An interesting possibility for disease intervention is the regular intake of natural food or herbal extracts, which contain active molecules that inhibit aggregation or induce the disassembly of misfolded aggregates. Among natural compounds, phenolic molecules are of particular interest, since most have dual activity as amyloid aggregation inhibitors and antioxidants. In this article, we review many phenolic natural compounds which have been reported in diverse model systems to have the potential to delay or prevent the development of various PMDs, including Alzheimer’s and Parkinson’s diseases, prion diseases, amyotrophic lateral sclerosis, systemic amyloidosis, and type 2 diabetes. The lower toxicity of natural compounds compared to synthetic chemical molecules suggest that they could serve as a good starting point to discover protein misfolding inhibitors that might be useful for the treatment of various incurable diseases. 相似文献