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Zusammenfassung Es wird gezeigt, dass Injektion von Rizinus-Extrakt die Plaque-Bildung im Jerne-Test fördert, was dafür spricht, dass die zytostatische Wirkung des Rizinus mit der Adjuvansfähigkeit gekoppelt ist.
We are greatly indebted to Drs. M.Funatsu and G.Funatsu for their supply for ricin and to Miss Y.Nagakawa for her excellent technical assistance. 相似文献
We are greatly indebted to Drs. M.Funatsu and G.Funatsu for their supply for ricin and to Miss Y.Nagakawa for her excellent technical assistance. 相似文献
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Subcutaneous transposition of the spleen enhances the survival rate following 90% hepatectomy in rats 总被引:1,自引:0,他引:1
Summary The effects of subcutaneous transposition of the spleen (STS) on the survival rate following 90% hepatectomy were investigated in rats. The survival rate was significantly higher in the STS group than in the non-STS group. Light microscopy enabled us to note that congestion in the terminal portal veins and sinusoids occurred either slightly earlier or to a higher degree in the non-STS group. 相似文献
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H.-O. Ito T. Ueda Y. Hashimoto T. Imoto T. Koga 《Cellular and molecular life sciences : CMLS》1997,53(1):51-60
We previously generated a monoclonal antibody (mAb) against a putative pathogenic epitope on native type II collagen (CII)
for the induction of collagen-induced arthritis in mice (mAb1), and an anti-idiotypic mAb which appears to possess the internal
image of the CII epitope (mAb2). In the present study, the structural basis of the antigen/mAb1 and mAb1/mAb2 interactions
was examined. When partially SH-reduced mAb1 was analysed on Western blots, only fragments containing both heavy (H) and light
(L) chains were recognized by mAb2. When mAb2 was partially SH-reduced, only fragments containing both H and L chains were
recognized by mAb1. H and L chains were separated from mAb1 in a reduced, denatured condition, and each chain and a mixture
of the two were refolded. mAb2 reacted specifically to the renatured whole IgG molecule of mAb1, but not to the refolded L
or to H chains. Recombinant single chain Fv (scFv) generated from mAb1 and mAb2 had properties of the original mAbs, whereas
genetical
ly constructed chimeric scFvs, consisting of VH from mAb1 and an irrelevant VL , or VL of mAb1 and an irrelevant VH , did not react either to CII or to mAb2. Thus, interactions among CII, mAb1 and mAb2 appear to depend on quaternary structures
containing different protein subunits. These observations support the internal image property of the mAb2. In addition, this
dependency on quaternary structure for recognition of proteins may also be relevant to other protein-protein interactions.
Received 29 July 1996; received after revision 13 September 1996; accepted 18 October 1996 相似文献
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E. Kounoue S. Nagafuchi M. Nakamura S. Nakano T. Koga M. Nakayama M. Mituyama Y. Niho R. Takaki 《Cellular and molecular life sciences : CMLS》1987,43(4):430-431
Summary
Corynebacterium parvum prevented the development of encephalomyocarditis virus-induced diabetes in mice, when it was given 3–14 days before the virus infection. This treatment inhibited virus replication in the pancreas of the infected mice at an early stage of the infection. 相似文献
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E Kounoue S Nagafuchi M Nakamura S Nakano T Koga M Nakayama M Mituyama Y Niho R Takaki 《Experientia》1987,43(4):430-431
Corynebacterium parvum prevented the development of encephalomyocarditis virus-induced diabetes in mice, when it was given 3-14 days before the virus infection. This treatment inhibited virus replication in the pancreas of the infected mice at an early stage of the infection. 相似文献
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R Iwakiri S Nagafuchi E Kounoue S Nakano T Koga M Nakayama M Nakamura Y Niho 《Experientia》1987,43(3):324-327
Cyclosporin A (CYA), when administered to CD-1 mice treated with a subdiabetogenic dose of Streptozocin (STZ), exacerbated the STZ-induced insulitis and elevated the plasma glucose levels, parallel to a reduction of the insulin content of the pancreas. The possible mechanisms of CYA-mediated aggravation of STZ-induced diabetes are discussed. 相似文献