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1.
Epithelial integrity in metazoan organs is maintained through the regulated proliferation and differentiation of organ-specific stem and progenitor cells. Although the epithelia of organs such as the intestine regenerate constantly and thus remain continuously proliferative, other organs, such as the mammalian urinary bladder, shift from near-quiescence to a highly proliferative state in response to epithelial injury. The cellular and molecular mechanisms underlying this injury-induced mode of regenerative response are poorly defined. Here we show in mice that the proliferative response to bacterial infection or chemical injury within the bladder is regulated by signal feedback between basal cells of the urothelium and the stromal cells that underlie them. We demonstrate that these basal cells include stem cells capable of regenerating all cell types within the urothelium, and are marked by expression of the secreted protein signal Sonic hedgehog (Shh). On injury, Shh expression in these basal cells increases and elicits increased stromal expression of Wnt protein signals, which in turn stimulate the proliferation of both urothelial and stromal cells. The heightened activity of this signal feedback circuit and the associated increase in cell proliferation appear to be required for restoration of urothelial function and, in the case of bacterial injury, may help clear and prevent further spread of infection. Our findings provide a conceptual framework for injury-induced epithelial regeneration in endodermal organs, and may provide a basis for understanding the roles of signalling pathways in cancer growth and metastasis. 相似文献
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G. C. Unnithan K. K. Nair Cathy J. Kooman 《Cellular and molecular life sciences : CMLS》1978,34(3):411-412
Summary Application of precocene II, topically or by contact method, appears to inhibit the synthetic activity of neurosecretory A-cells of the pars intercerebralis ofOncopeltus fasciatus. Treatment of precocene-treated insects with JH III apparently stimulates the secretory activity of these cells.Supported by National Research Council of Canada grant No. A4669.We thank Dr G. B. Staal, Zoecon Corporation, Palo Alto, California, for the gift of precocene II. 相似文献
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P. P. Nair 《Cellular and molecular life sciences : CMLS》1960,16(5):193-194
Résumé Un nouveau produit crystallin de l'acide folique avec l'acide molybdophosphorique est décrit. Ce produit a été soumis aux examens microscopique, électrophorétique et analyse élémentaire. Ce produit provoque une leucopénie chez les rats albines, ce qui indique une ressemblance probable aux antidotes de l'acide folique. D'autre part, l'observation a montré que ce produit a un effet inhibitif sur la croissance desStreptococcus faecalis R. dans des cultures renfermant de l'acide folique à des degrés différents. 相似文献
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Zusammenfassung Es wird die genetische Aktivität der Zellkerne in den akzessorischen Drüsen vonPeriplaneta americana durch Juvenilhormon gesteigert, ein Nachweis, der mittels Autoradiographie nach «Anfärbung» mit3H-Actinomyzin-D erbracht werden konnte.
The research was supported by National Research Council of Canada operating grant No. A4669 awarded to Dr.K. K. Nair. We thank Dr.J. B. Siddall of Zoecon for the generous gift of the juvenile hormone analogue. 相似文献
The research was supported by National Research Council of Canada operating grant No. A4669 awarded to Dr.K. K. Nair. We thank Dr.J. B. Siddall of Zoecon for the generous gift of the juvenile hormone analogue. 相似文献
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Silica nanoparticles have been prepared from tetraethylorthosilicate dissolved in ethanol followed by base-catalyzed condensation.Earlier works reported that at least four parameters,namely concentrati... 相似文献
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K. K. Nair 《Cellular and molecular life sciences : CMLS》1958,14(5):172-173
Résumé On a étudié l'effet de divers fixateurs histologiques sur l'activité de la ribonucléase et discuté la signification des résultats pour le travail cytologique. 相似文献
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