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Colleen McBride and colleagues argue that progress on a multifaceted research agenda is necessary to reap the full benefits and avoid the potential pitfalls of the emerging area of personalized genomics. They also outline one element of this agenda, the Multiplex Initiative, which has been underway since 2006. 相似文献
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Feline leukaemia virus (FeLV) is epidemiologically associated with induction of the majority of lymphoid tumours of the domestic cat. However, about one-third of these tumours are devoid of exogenous virus or show evidence of virus integration only after tumour outgrowth. To help define the genetic mechanisms of feline lymphomagenesis we have explored here the possibility that cellular oncogenes (c-onc genes) are rearranged in tumour cell DNA. Of 16 FeLV-positive T-cell tumours among 31 naturally occurring lymphomas, 2 showed evidence of recombinant FeLV proviruses containing myc oncogene sequences. One of the two produced a transmissible myc-containing FeLV. In both cases c-myc and its surrounding DNA appeared unaltered. We believe that the association of myc with FeLV may result in its activation and play a part in the development of a significant fraction of cat T-cell lymphomas. Our findings contrast with studies of experimental induction of chicken lymphoma, in which myc activation occurs by retrovirus promoter insertion near c-myc (refs 3-5), rather than by incorporation into virus. 相似文献
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Intestinal transport of cystine analogues 总被引:1,自引:0,他引:1
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Zusammenfassung Bei kastrierten, weiblichen Mäusen, die verschiedene Cytostatica zusammen mit einem langwirkenden Oestrogen erhielten, wurde Gewichtszunahme und Eosinophilie des Uterus nach 11 Tagen gemessen. Zwischen den beiden Wirkungen bestanden offensichtlich keine Beziehungen. Das DNA/RNA Verhältnis blieb unverändert. 相似文献
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Intercellular space in normal human stratum corneum 总被引:1,自引:0,他引:1
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