西红花苷生源途径解析及其合成生物学研究进展

天然产物是新药研发的重要资源,具有显著的抗疟疾、抗肿瘤、抗病毒感染等作用.珍稀名贵中药西红花的活性成分为西红花苷,属于脱辅基类胡萝卜素类化合物,具有保护中枢神经系统及预防心脑血管疾病的药理活性.西红花苷资源匮乏、价格高昂,极大限制其药物开发及临床应用.本文从西红花苷的化学表征、生物合成途径解析及合成生物学研究进行综述,展示了西红花苷的光谱学和质谱学特征,阐述其完整生物合成途径的解析,介绍了利用微生物细胞工厂生产5种西红花苷的最新突破.据此,进一步提出开展不同物种西红花苷生物合成途径关键酶的进化机制、合成生物学关键技术探索和条件优化等研究,以推动西红花苷工业化生产及新药研发,为西红花苷来源的中药资源可持续发展提供理论基础和方法指导.     

Web-Based Data Management and Sharing System for Electron Proke Micro-analysis

This paper proposes a useful web-based system for the management and sharing of electron probe micro-analysis( EPMA)data in geology. A new web-based architecture that integrates the management and sharing functions is developed and implemented.Earth scientists can utilize this system to not only manage their data,but also easily communicate and share it with other researchers.Data query methods provide the core functionality of the proposed management and sharing modules. The modules in this system have been developed using cloud GIS technologies,which help achieve real-time spatial area retrieval on a map. The system has been tested by approximately 263 users at Jilin University and Beijing SHRIMP Center. A survey was conducted among these users to estimate the usability of the primary functions of the system,and the assessment result is summarized and presented.     

融资租赁将成为我国资本市场的生力军

回顾我国融资租赁市场发展的二十多年的历程;解读融资租赁这一融资渠道在现代国家资本市场中的重要作用;分析目前我国融资租赁市场的主要问题;阐明融资租赁乃我国资本市场的生力军,其发展前景十分广阔。