排序方式: 共有36条查询结果,搜索用时 15 毫秒
1.
Y. Ueno I. Ueno K. Ito T. Tatsuno 《Cellular and molecular life sciences : CMLS》1967,23(12):1001-1002
Résumé La lutéoskyrine, pigment cartinogène synthétisé par lePenicillium islandicum Sopp, inhibe la synthèse du RNA nucléaire dans la cellule de la tumeur Ehrlich. 相似文献
2.
Zusammenfassung Anschwellung und Lysis von Mitochondrien im Reagenzglas (in vivo), durch Zugabe von Glutathiongemisch zur Nährlösung verursacht, wurde elektronenmikroskopisch geprüft. Die Mitochondrien wurden in Mäuseleberzellen nach i.p. Injektion zusammen mit dem Glutathiongemisch untersucht. 相似文献
3.
Y. Ueno I. Ueno T. Tatsuno K. Ohokubo H. Tsunoda 《Cellular and molecular life sciences : CMLS》1969,25(10):1062
Zusammenfassung Fusarenon-X, ein toxisches Produkt aus dem Kulturfiltrat vonFusarium nivale wurde isoliert, näher charakterisiert und dessen Struktur ermittelt. 相似文献
4.
5.
Evidence from fluid inclusions for microbial methanogenesis in the early Archaean era 总被引:5,自引:0,他引:5
Methanogenic microbes may be one of the most primitive organisms, although it is uncertain when methanogens first appeared on Earth. During the Archaean era (before 2.5 Gyr ago), methanogens may have been important in regulating climate, because they could have provided sufficient amounts of the greenhouse gas methane to mitigate a severely frozen condition that could have resulted from lower solar luminosity during these times. Nevertheless, no direct geological evidence has hitherto been available in support of the existence of methanogens in the Archaean period, although circumstantial evidence is available in the form of approximately 2.8-Gyr-old carbon-isotope-depleted kerogen. Here we report crushing extraction and carbon isotope analysis of methane-bearing fluid inclusions in approximately 3.5-Gyr-old hydrothermal precipitates from Pilbara craton, Australia. Our results indicate that the extracted fluids contain microbial methane with carbon isotopic compositions of less than -56 per thousand included within original precipitates. This provides the oldest evidence of methanogen (> 3.46 Gyr ago), pre-dating previous geochemical evidence by about 700 million years. 相似文献
6.
L. Wetterberg F. Halberg B. Tarquini M. Cagnoni E. Haus K. Griffith T. Kawasaki Lee-Anne Wallach Michio Ueno K. Uezo M. Matsuoka Marilyn Kuzel Erna Halberg T. Omae 《Cellular and molecular life sciences : CMLS》1979,35(3):416-419
Summary Urinary melatonin excretion is lower in East-Asian (Japanese) than in North-American (whites of mixed ethnic origin) women. Moreover, a statistically significant circadian rhythm is demonstrated by population-mean cosinor in the data pool from both groups of women. Furthermore, statistical significance characterizes interactions of effects from geographic differences (between ethnic groups) with temporal factors. Such spatio-temporal interactions await further scrutiny with a view inter alia of carcinogenesis as it is influenced by a spectrum of intermodulating rhythms.Supported by U.S. Public Health Service (5-K6-GM-13981-17), National Cancer Institute (1R01-CA-14445-05 and N01-CP-5-5702), National Institute of Occupational Safety and Health (OH-00631-01), National Institute of Aging (AG-00158), Environmental Protection Agency (R804513-01-0), Swedish Medical Research Council grant 3371 and the St Paul Ramsey Medical Research and Education Foundation. R.B. Sothern and Jung-Keun Lee, Scientists, Chronobiology Laboratories, University of Minnesota provided valuable help. 相似文献
7.
Fujimoto A Totoki Y Abe T Boroevich KA Hosoda F Nguyen HH Aoki M Hosono N Kubo M Miya F Arai Y Takahashi H Shirakihara T Nagasaki M Shibuya T Nakano K Watanabe-Makino K Tanaka H Nakamura H Kusuda J Ojima H Shimada K Okusaka T Ueno M Shigekawa Y Kawakami Y Arihiro K Ohdan H Gotoh K Ishikawa O Ariizumi S Yamamoto M Yamada T Chayama K Kosuge T Yamaue H Kamatani N Miyano S Nakagama H Nakamura Y Tsunoda T Shibata T Nakagawa H 《Nature genetics》2012,44(7):760-764
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. We sequenced and analyzed the whole genomes of 27 HCCs, 25 of which were associated with hepatitis B or C virus infections, including two sets of multicentric tumors. Although no common somatic mutations were identified in the multicentric tumor pairs, their whole-genome substitution patterns were similar, suggesting that these tumors developed from independent mutations, although their shared etiological backgrounds may have strongly influenced their somatic mutation patterns. Statistical and functional analyses yielded a list of recurrently mutated genes. Multiple chromatin regulators, including ARID1A, ARID1B, ARID2, MLL and MLL3, were mutated in ~50% of the tumors. Hepatitis B virus genome integration in the TERT locus was frequently observed in a high clonal proportion. Our whole-genome sequencing analysis of HCCs identified the influence of etiological background on somatic mutation patterns and subsequent carcinogenesis, as well as recurrent mutations in chromatin regulators in HCCs. 相似文献
8.
Ueno K Ueda T Sakai K Abe Y Hamasaki N Okamoto M Imoto T 《Cellular and molecular life sciences : CMLS》2005,62(2):199-205
We examined chemical reactions in mouse lysozyme after incubation under physiological conditions (pH 7 and 37°C). After incubation for 8 weeks, racemization was observed specifically at Asn127 among the 19 Asp/Asn residues in mouse lysozyme. Furthermore, analysis of the primary structure showed that the racemized residue was not Asp, but Asn, which demonstrates that deamidation and isomerization did not occur. These results mean that this racemization occurs without forming a succinimide intermediate. This is the first example of D-asparaginyl formation in a protein occurring during the racemization process under physiological conditions.Received 16 September 2004; received after revision 26 October 2004; accepted 12 November 2004 相似文献
9.
10.