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Alcaïs A Alter A Antoni G Orlova M Nguyen VT Singh M Vanderborght PR Katoch K Mira MT Vu HT Ngyuen TH Nguyen NB Moraes M Mehra N Schurr E Abel L 《Nature genetics》2007,39(4):517-522
Host genetics has an important role in leprosy, and variants in the shared promoter region of PARK2 and PACRG were the first major susceptibility factors identified by positional cloning. Here we report the linkage disequilibrium mapping of the second linkage peak of our previous genome-wide scan, located close to the HLA complex. In both a Vietnamese familial sample and an Indian case-control sample, the low-producing lymphotoxin-alpha (LTA)+80 A allele was significantly associated with an increase in leprosy risk (P = 0.007 and P = 0.01, respectively). Analysis of an additional case-control sample from Brazil and an additional familial sample from Vietnam showed that the LTA+80 effect was much stronger in young individuals. In the combined sample of 298 Vietnamese familial trios, the odds ratio of leprosy for LTA+80 AA/AC versus CC subjects was 2.11 (P = 0.000024), which increased to 5.63 (P = 0.0000004) in the subsample of 121 trios of affected individuals diagnosed before 16 years of age. In addition to identifying LTA as a major gene associated with early-onset leprosy, our study highlights the critical role of case- and population-specific factors in the dissection of susceptibility variants in complex diseases. 相似文献
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General linear non-autonomous functional differential equations are considered. Explicit criteria for exponential stability are given. Furthermore, the authors present an explicit robust stability bound for systems subject to time-varying perturbations. Two examples are given to illustrate the obtained results. 相似文献
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炼油厂生产属于连续性生产,生产作业控制一般采用流量控制模式,然而,影响生产的因素,如故障、原油供应、门牌号销售等多具有随机性,而且在生产作业中,许多是经验性的东西,本文首次将Fuzzy控制方法引入石化企业炼油生产作业计算机控制系统中。 相似文献
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Our earlier serum electrophoretic study in 'lethargic' mutant mice showed that the quantity of protein in 1 band is inversely related to the size of the spleen. In this study, we demonstrate that this protein band almost entirely disappears in mice with splenomegaly following spontaneous skin infection. The results suggest that this serum protein may play a role in regulating growth of lymphoid tissue. 相似文献
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Van-Phuc Dinh Ngoc Quyen Tran Nguyen-Que-Tran Le Quang-Huy Tran Trinh Duy Nguyen Van Tan Le 《自然科学进展(英文版)》2019,29(6):648-654
A facile and simple chemical precipitation method was utilized to synthesize FeFe_2O_4 magnetic nanomaterial for removing methylene blue(MB) from aqueous solution. Characterizations of this material were examined by using XRD, SEM, FT-IR, TGA-DTG and BET methods. Factors affecting the uptake of methylene blue, including p H, adsorption time, and MB initial concentration were also studied. The measured data were fitted by using four isotherm models including Langmuir, Freundlich, Sips and Temkin. Results showed that the Sips model offers the best fit to the data. In addition, the monolayer MB adsorption capacity obtained from the Langmuir model was 42.35 mg g~(-1) under the optimal conditions of p H = 10 and adsorption time = 80 min. In particular, the uptake of MB onto FeFe_2O_4 magnetic nanomaterial obtained from the kinetic and mechanism studies of the adsorption was in good agreement with prediction of the pseudo-first-order model, whereas the electrostatic interaction was found to play a primary mechanism. 相似文献
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Thi Ngoc Tram Nguyen Diem-Huong Nguyen-Tran Long Giang Bach Tran Hoang Du Truong Ngoc Thuy Trang Le Dai Hai Nguyen 《自然科学进展(英文版)》2019,29(6):612-616
A hybrid of organic/inorganic system, hollow mesoporous silica nanoparticles functionalized with poly(ethylene glycol), was synthesized in the presence of coupling agent and aminated ends. Doxorubicin (DOX) was used as a model drug to evaluate the effect of PEGylation on the loading capacity and release pattern of the system. Characterization with transmission electron microscopy (TEM) and scanning electron microscopy (SEM), X-ray diffraction (XRD), nitrogen adsorption-desorption, thermogravimetric analysis (TGA) and Fourier transformed infrared (FTIR) confirmed the PEG conjugation, as well as the amorphous mesoporous nature of the synthesized particles. Due to the capping effect of PEG molecules over the pores in the silica structure, the synthesized system was able to retain higher amount of cargo and establish a controlled manner when releasing. 相似文献
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总结了利用磁场处理水提高混凝土强度和减少水泥用量的试验研究结果。在室温下,以某一流动速度的水通过某一强度的磁场时垂直切割磁力线,这种磁场处理水用于搅拌混凝土,可使混凝土的强度提高5% ̄12%,减少水泥用量5% ̄10%,这一成果若推广到生产中,必将产生较大的经济效益。 相似文献
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Summary Our earlier serum electrophoretic study in lethargic mutant mice showed that the quantity of protein in 1 band is inversely related to the size of the spleen. In this study, we demonstrate that this protein band almost entirely disappears in mice with splenomegaly following spontaneous skin infection. The results suggest that this serum protein may play a role in regulating growth of lymphoid tissue.This study is made possible through support of Medical Research Service of the US Veterans Administration. We thank Dr Thomas B. Pool, Department of Anatomy, The University of Texas Health Science Center, for editorial assistance. 相似文献
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通过对抗苹果树皮腐烂病抗生素S—921菌株特性的研究,发现其特性基本属于不吸水链霉菌类群但与不吸水链霉菌又不完全相同,因此,我们认为它是一个新的变种。 相似文献