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Aiertza MK Odriozola I Cabañero G Grande HJ Loinaz I 《Cellular and molecular life sciences : CMLS》2012,69(3):337-346
The synthesis of polymer nanoparticles (NPs) with controlled characteristics has become an appealing research topic lately.
Nanomedicine, and especially drug delivery and imaging, are fields that require particles of a controlled size and with a
tailored arrangement of functional groups. Intramolecular cross-linking or collapse of single polymer chains has emerged as
an efficient alternative for the synthesis of well-defined polymer NPs. This technique allows the generation of 1.5–20 nm
particles with a wide variety of chemical compositions and functionalities. This review begins by gathering synthetic strategies
described in the literature and groups them into four main synthetic methods: homo-functional collapse, hetero-functional
collapse, crosslinker-mediated collapse, and one-block collapse of diblock or triblock copolymers. Afterwards, the main characterization
techniques and physical properties of single-chain polymer NPs (SCPNs) are exposed. Finally, several applications in nanomedicine
are mentioned followed by some future perspectives. 相似文献
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Systemic Practice and Action Research - Institutionalization is one of the challenges met by action research (AR) processes aiming at structural changes in society, but what institutionalizing AR... 相似文献
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