排序方式: 共有28条查询结果,搜索用时 62 毫秒
1.
The focus with which the paper is concerned is the process or task of intervention and, more specifically, the exploration of three (overlapping and interacting) questions pertinent to those who would intervene: What is to be done? How shall we decide what to do? What can guide our actions? In terms of what we will describe as pragmatic pluralism (our response to these questions), we intend this to be read in several different ways and on several different levels. Illustrating the discussion with examples from a number of different case studies, we will talk about pluralism in each of the following features: in the use of specific methods/techniques in the role(s) of the interventionists in the modes of representation employed in the use of different rationalities in the ‘nature’ of the client 相似文献
2.
3.
4.
Rohmann E Brunner HG Kayserili H Uyguner O Nürnberg G Lew ED Dobbie A Eswarakumar VP Uzumcu A Ulubil-Emeroglu M Leroy JG Li Y Becker C Lehnerdt K Cremers CW Yüksel-Apak M Nürnberg P Kubisch C Kubisch C Schlessinger J van Bokhoven H Wollnik B 《Nature genetics》2006,38(4):414-417
Lacrimo-auriculo-dento-digital (LADD) syndrome is characterized by lacrimal duct aplasia, malformed ears and deafness, small teeth and digital anomalies. We identified heterozygous mutations in the tyrosine kinase domains of the genes encoding fibroblast growth factor receptors 2 and 3 (FGFR2, FGFR3) in LADD families, and in one further LADD family, we detected a mutation in the gene encoding fibroblast growth factor 10 (FGF10), a known FGFR ligand. These findings increase the spectrum of anomalies associated with abnormal FGF signaling. 相似文献
5.
He XC Yin T Grindley JC Tian Q Sato T Tao WA Dirisina R Porter-Westpfahl KS Hembree M Johnson T Wiedemann LM Barrett TA Hood L Wu H Li L 《Nature genetics》2007,39(2):189-198
Intestinal polyposis, a precancerous neoplasia, results primarily from an abnormal increase in the number of crypts, which contain intestinal stem cells (ISCs). In mice, widespread deletion of the tumor suppressor Phosphatase and tensin homolog (PTEN) generates hamartomatous intestinal polyps with epithelial and stromal involvement. Using this model, we have established the relationship between stem cells and polyp and tumor formation. PTEN helps govern the proliferation rate and number of ISCs and loss of PTEN results in an excess of ISCs. In PTEN-deficient mice, excess ISCs initiate de novo crypt formation and crypt fission, recapitulating crypt production in fetal and neonatal intestine. The PTEN-Akt pathway probably governs stem cell activation by helping control nuclear localization of the Wnt pathway effector beta-catenin. Akt phosphorylates beta-catenin at Ser552, resulting in a nuclear-localized form in ISCs. Our observations show that intestinal polyposis is initiated by PTEN-deficient ISCs that undergo excessive proliferation driven by Akt activation and nuclear localization of beta-catenin. 相似文献
6.
7.
Birth of the D-E-A-D box 总被引:108,自引:0,他引:108
P Linder P F Lasko M Ashburner P Leroy P J Nielsen K Nishi J Schnier P P Slonimski 《Nature》1989,337(6203):121-122
8.
9.
10.
Leroy EM Kumulungui B Pourrut X Rouquet P Hassanin A Yaba P Délicat A Paweska JT Gonzalez JP Swanepoel R 《Nature》2005,438(7068):575-576
The first recorded human outbreak of Ebola virus was in 1976, but the wild reservoir of this virus is still unknown. Here we test for Ebola in more than a thousand small vertebrates that were collected during Ebola outbreaks in humans and great apes between 2001 and 2003 in Gabon and the Republic of the Congo. We find evidence of asymptomatic infection by Ebola virus in three species of fruit bat, indicating that these animals may be acting as a reservoir for this deadly virus. 相似文献